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SARS-CoV-2 Kappa variant: Difference between revisions

SARS-CoV-2 Kappa variant (edit)

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* [[Variants of SARS-CoV-2#L452R|L452R]]. The substitution at position 452, a leucine-to-arginine substitution. This exchange confers stronger affinity of the spike protein for the ACE2 receptor along with decreased recognition capability of the immune system.<ref name=SGDB>{{cite journal |last1=Starr |first1=Tyler N. |last2=Greaney |first2=Allison J. |last3=Dingens |first3=Adam S. |last4=Bloom |first4=Jesse D. |title=Complete map of SARS-CoV-2 RBD mutations that escape the monoclonal antibody LY-CoV555 and its cocktail with LY-CoV016 |journal=Cell Reports Medicine |date=April 2021 |volume=2 |issue=4 |pages=100255 |doi=10.1016/j.xcrm.2021.100255 |pmid=33842902 |pmc=8020059 |doi-access=free |access-date=}}</ref><ref name=ZDCSPV>{{cite journal |last1=Zhang |first1=Wenjuan |last2=Davis |first2=Brian D. |last3=Chen |first3=Stephanie S. |last4=Sincuir Martinez |first4=Jorge M. |last5=Plummer |first5=Jasmine T. |last6=Vail |first6=Eric |title=Emergence of a Novel SARS-CoV-2 Variant in Southern California |journal=JAMA |date=6 April 2021 |volume=325 |issue=13 |pages=1324–1326 |doi=10.1001/jama.2021.1612|pmid=33571356 |pmc=7879386 |doi-access=free }}</ref>
* [[Variants of SARS-CoV-2#L452R|L452R]]. The substitution at position 452, a leucine-to-arginine substitution. This exchange confers stronger affinity of the spike protein for the ACE2 receptor along with decreased recognition capability of the immune system.<ref name=SGDB>{{cite journal |last1=Starr |first1=Tyler N. |last2=Greaney |first2=Allison J. |last3=Dingens |first3=Adam S. |last4=Bloom |first4=Jesse D. |title=Complete map of SARS-CoV-2 RBD mutations that escape the monoclonal antibody LY-CoV555 and its cocktail with LY-CoV016 |journal=Cell Reports Medicine |date=April 2021 |volume=2 |issue=4 |pages=100255 |doi=10.1016/j.xcrm.2021.100255 |pmid=33842902 |pmc=8020059 |doi-access=free |access-date=}}</ref><ref name=ZDCSPV>{{cite journal |last1=Zhang |first1=Wenjuan |last2=Davis |first2=Brian D. |last3=Chen |first3=Stephanie S. |last4=Sincuir Martinez |first4=Jorge M. |last5=Plummer |first5=Jasmine T. |last6=Vail |first6=Eric |title=Emergence of a Novel SARS-CoV-2 Variant in Southern California |journal=JAMA |date=6 April 2021 |volume=325 |issue=13 |pages=1324–1326 |doi=10.1001/jama.2021.1612|pmid=33571356 |pmc=7879386 |doi-access=free }}</ref>
* [[Variants of SARS-CoV-2#E484Q|E484Q]]. The substitution at position 484, a glutamic acid-to-glutamine substitution. This alteration confers the variant stronger binding potential to [[hACE2|Angiotensin-converting enzyme 2]], as well as better ability to evade hosts' immune systems.<ref name=Haseltine/><ref>{{cite journal |last1=Harvey |first1=WT |last2=Carabelli |first2=AM |last3=Jackson |first3=B |last4=Gupta |first4=RK |last5=Thomson |first5=EC |last6=Harrison |first6=EM |last7=Ludden |first7=C |last8=Reeve |first8=R |last9=Rambaut |first9=A |last10=Peacock |first10=SJ |last11=Robertson |first11=DL |display-authors=6 |title=SARS-CoV-2 variants, spike mutations and immune escape |url= |journal=Nat Rev Microbiol |year=2021 |volume= 19|issue= 7|pages= 409–424|doi=10.1038/s41579-021-00573-0 |pmid=34075212 |pmc=8167834 |quote=''For example, recently detected viruses of lineage B.1.617.1 were anticipated to show altered antigenicity due to the presence of the substitutions L452R and E484Q, which have been described as affecting antibody recognition.''}}</ref>
* [[Variants of SARS-CoV-2#E484Q|E484Q]]. The substitution at position 484, a glutamic acid-to-glutamine substitution. This alteration confers the variant stronger binding potential to [[hACE2|Angiotensin-converting enzyme 2]], as well as better ability to evade hosts' immune systems.<ref name=Haseltine/><ref>{{cite journal |last1=Harvey |first1=WT |last2=Carabelli |first2=AM |last3=Jackson |first3=B |last4=Gupta |first4=RK |last5=Thomson |first5=EC |last6=Harrison |first6=EM |last7=Ludden |first7=C |last8=Reeve |first8=R |last9=Rambaut |first9=A |last10=Peacock |first10=SJ |last11=Robertson |first11=DL |display-authors=6 |title=SARS-CoV-2 variants, spike mutations and immune escape |url= |journal=Nat Rev Microbiol |year=2021 |volume= 19|issue= 7|pages= 409–424|doi=10.1038/s41579-021-00573-0 |pmid=34075212 |pmc=8167834 |quote=''For example, recently detected viruses of lineage B.1.617.1 were anticipated to show altered antigenicity due to the presence of the substitutions L452R and E484Q, which have been described as affecting antibody recognition.''}}</ref>
* [[Variants of SARS-CoV-2#P681R|P681R]]. The substitution at position 681, a proline-to-arginine substitution.<ref name="CDC Variants">{{cite web |url=https://www.cdc.gov/coronavirus/2019-ncov/cases-updates/variant-surveillance/variant-info.html |title=SARS-CoV-2 Variant Classifications and Definitions |website=cdc.org |date=11 February 2020 |publisher=[[Centers for Disease Control and Prevention]]|access-date=2021-06-07}}</ref><ref name=Haseltine>{{cite news |last1=Haseltine |first1=William |title=An Indian SARS-CoV-2 Variant Lands In California. More Danger Ahead? |url=https://www.forbes.com/sites/williamhaseltine/2021/04/12/an-indian-sars-cov-2-variant-lands-in-california-more-danger-ahead/?sh=1ff3056b3b29 |access-date=2021-06-07 |work=Forbes |language=en}}</ref>
* [[Variants of SARS-CoV-2#P681R|P681R]]. The substitution at position 681, a proline-to-arginine substitution.<ref name=Haseltine>{{cite news |last1=Haseltine |first1=William |title=An Indian SARS-CoV-2 Variant Lands In California. More Danger Ahead? |url=https://www.forbes.com/sites/williamhaseltine/2021/04/12/an-indian-sars-cov-2-variant-lands-in-california-more-danger-ahead/?sh=1ff3056b3b29 |access-date=2021-06-07 |work=Forbes |language=en}}</ref><ref name="CDC Variants">{{cite web |url=https://www.cdc.gov/coronavirus/2019-ncov/cases-updates/variant-surveillance/variant-info.html |title=SARS-CoV-2 Variant Classifications and Definitions |website=cdc.org |date=11 February 2020 |publisher=[[Centers for Disease Control and Prevention]]|access-date=2021-06-07}}</ref>


The European Centre for Disease Prevention and Control (ECDC) also list a fourth spike mutation of interest:<ref>{{Cite web|title=SARS-CoV-2 variants of concern as of 3 June 2021|date=3 June 2021|url=https://www.ecdc.europa.eu/en/covid-19/variants-concern|access-date=2021-06-08|website=European Centre for Disease Prevention and Control }}</ref>  
The European Centre for Disease Prevention and Control (ECDC) also list a fourth spike mutation of interest:<ref>{{Cite web|title=SARS-CoV-2 variants of concern as of 3 June 2021|date=3 June 2021|url=https://www.ecdc.europa.eu/en/covid-19/variants-concern|access-date=2021-06-08|website=European Centre for Disease Prevention and Control }}</ref>  
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