File:Diagnostics-10-00453-g001.webp

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DescriptionDiagnostics-10-00453-g001.webp
English: The human antibody response to SARS-CoV-2 infection. (1) The SARS-CoV-2 virus enters the host cell via interaction between viral spike (S) and host angiotensin-converting enzyme 2 (ACE2) proteins. (2,3) Following replication and release from the host cells, a subset of viruses will be engulfed and digested by antigen-presenting cells (APCs) like macrophages or dendritic cells. (4) Fragmented SARS-CoV-2 antigen(s) will be presented to T helper cells, which in turn will interact and activate B cells. (5) Activated B cells will proliferate and differentiate into plasma or memory B cells with high-affinity binding receptors for the original SARS-CoV-2 antigen. Plasma cells secrete their SARS-CoV-2-specific receptors in the form of IgM, IgG, or IgA antibodies. (6) Antibody-mediated neutralization occurs when SARS-CoV-2-specific antibodies bind to viral antigen(s) and prevent virus interaction and entry into host cells.
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Ghaffari, A.; Meurant, R.; Ardakani, A. COVID-19 Serological Tests: How Well Do They Actually Perform? Diagnostics 2020, 10, 453.

https://doi.org/10.3390/diagnostics10070453
Author Abdi Ghaffari, Robyn Meurant, and Ali Ardakani

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The human antibody response to SARS-CoV-2 infection.

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4 July 2020

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3,590 × 1,991 (1.58 MB)smartcommons>Guest2625Uploaded a work by Abdi Ghaffari, Robyn Meurant, and Ali Ardakani from Ghaffari, A.; Meurant, R.; Ardakani, A. COVID-19 Serological Tests: How Well Do They Actually Perform? Diagnostics 2020, 10, 453. https://doi.org/10.3390/diagnostics10070453 with UploadWizard

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