This is the list of the scientists from Tamil Origin or Tamil Nadu
- Thomas Anantharaman
- Kailasavadivoo Sivan
- Mylswamy Annadurai
- V. S. R. Arunachalam
- Subrahmanyan Chandrasekhar
- Rajagopala Chidambaram
- Elagu V. Elaguppillai
- Mirudhubashini Govindarajan
- Ravindran Kannan
- Poondi Kumaraswamy
- C. Mohan
- A. Sivathanu Pillai
- G. N. Ramachandran
- Venkatraman Ramakrishnan
- C. V. Raman
- Shan Ratnam
- Ramaswami Venkataswami
- Ganapathi Thanikaimoni
- P. S. Veeraraghavan
- Ramanuja Vijayaraghavan
- A. P. J. Abdul Kalam
- Kariamanickam Srinivasa Krishnan
- G. V. Loganathan
- Mahadeva Subramania Mani
- Ramanujam Varatharaja Perumal
- M. Pitchaimani
- Venkatraman Radhakrishnan
- Vilayanur S. Ramachandran
- Srinivasa Ramanujan
- S. R. Ranganathan
- Mohammed Rela
- Vaidhyanathaswamy Santhanam
- W Selvamurthy
- Shiva Ayyadurai
- M. S. Swaminathan
- Bhargav Sri Prakash