The following people were born or based their life in Vellore.
Education
- V. L. Ethiraj, Founder, Ethiraj College for Women
- G. Viswanathan, Founder and chancellor, VIT University
- V. M. Muralidharan, Former Chairman, Ethiraj College for Women
- Benjamin Pulimood, was the Director/Principal, Christian Medical College & Hospital
Entrepreneurs
- Mecca Rafeeque Ahmed, Founder and Managing Director of FARIDA Group
Films and Entertainments
- Viswanathan Ravichandran, also known as (Aascar V. Ravichandran) is an Indian film producer and distributor
- Aravinnd Singh, Cinematographer of Tamil films Demonte Colony and Aarathu Sinam
- Dinesh Ravi, Tamil actor of Attakathi and Visaaranai fame
- Vishnu Vishal, Tamil actor
- Bhaskar, Director of Bommarilu, Paragu, Orange, Ongole Githa, Bangalore Naatkal
- Aryan (actor), Indian film actor
- R. Nataraja Mudaliar, known as the father of Tamil cinema, was a pioneer in the production of silent films
- Vellore A. R. Srinivasan, classical Carnatic musician
- Vani Jairam, playback singer
- N. Viswanathan, Bengali Actor
- Thiru, Tamil film director
- Radhika Apte, Bollywood Actress
- Indhuja Ravichandran, Tamil film Actress
Politics
- V. S. Vijay, Indian politician and incumbent member of the Tamil Nadu legislative assembly from Vellore constituency and Ex-Minister for Health, Govt. of Tamil Nadu
- Abdul Rahman, Indian politician and former member of the Parliament of India from Vellore Constituency
- C. Abdul Hakim, Indian politician and businessman
- C. Gnanasekaran, Indian politician and former Member of the Legislative Assembly of Tamil Nadu
- Durai Murugan, Indian politician and Ex-Minister for Public Works, Govt. of Tamil Nadu
Sports
- M Tamil Selvan, won silver medal in 1978 & 1982 Commonwealth Games.
- Sathish Sivalingam, Won gold medal in 77 kg category in 2014 & 2018 Commonwealth Games.
- Palani Amarnath, former Player of IPL chennai Superkings and Tamilnadu Ranji Trophy.
Scientists
- C. Mohan, Well known computer scientist in Silicon Valley, an IBM Fellow and the former IBM India Chief Scientist.
Writers
- Azhagiya Periyavan (pen name of C.Aravindan), journalist and author