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{{Use dmy dates|date=January 2019}}
{{Use Indian English|date=January 2019}}
{{Infobox scientist
| name = Y. D. Sharma
| image =
| alt =
| caption =
| birth_date = {{Birth date and age|1951|7|22|df=y}}
| birth_place = [[Gangtok, Sikkim|Gangtok]], [[Sikkim]], India
| death_date =
| death_place =
| residence =
| fields = {{ublist | [[Molecular biology]] }}
| workplaces = {{ublist | [[National Institute of Malaria Research]] | [[AIIMS Delhi]] }}
| alma_mater = {{ublist | [[Agra University]] | [[M. J. P. Rohilkhand University]] | [[AIIMS Delhi]] | [[University of Connecticut Health Center]] | [[Public Health Research Institute]] }}
| doctoral_advisor = {{ublist | Marvin Lawrence Tanzer }}
| doctoral_students =
| known_for = Studies on molecular biology of [[malaria]]
| awards = {{ublist| 1994 [[Shanti Swarup Bhatnagar Prize]] | 1997 Dr. M.O.T. Iyangar Memorial Prize | 2001 National Academy of Vector Borne Diseases Award }}
}}
'''Yagya Dutta Sharma''' (born 22 July 1951) is an Indian molecular biologist, professor and head of the department of biotechnology at the [[All India Institute of Medical Sciences, Delhi]]. An elected fellow of all three major Indian science academies — [[Indian National Science Academy]], [[Indian Academy of Sciences]], and [[National Academy of Sciences, India]] — Sharma is known for his research on the molecular biology of [[malaria]]. The [[Council of Scientific and Industrial Research]], the apex agency of the Government of India for scientific research, awarded him the [[Shanti Swarup Bhatnagar Prize for Science and Technology]] for his contributions to medical sciences in 1994.

== Biography ==
[[File:AIIMS central lawn.jpg|thumb|235px|All India Institute of Medical Sciences, Delhi]]
Born on 22 July 1951, Y. D. Sharma did his early college studies at [[Dr. Bhimrao Ambedkar University]] (formerly known as Agra University) from where he earned his bachelor's (BSc) and master's (MSc) degrees.<ref name="Indian fellow - Y D Sharma">{{Cite web |url=http://insaindia.res.in/detail/P06-1423 |title=Indian fellow - Y D Sharma |date=2017 |publisher=Indian National Science Academy |access-date=21 October 2017 |archive-date=6 February 2020 |archive-url=https://web.archive.org/web/20200206113328/http://insaindia.res.in/detail/P06-1423 |url-status=dead }}</ref> Subsequently, he did his doctoral studies at [[M. J. P. Rohilkhand University]] and after securing a PhD for his thesis on ''serum [[glycoproteins]]'' in 1981, he did the first part of his post-doctoral work at the [[All India Institute of Medical Sciences, Delhi]] where his work was based on [[Dental fluorosis|fluorosis]]. Moving to the [[University of Connecticut Health Center]] in 1982, Sharma continued his post-doc work at the laboratory of Marvin Lawrence Tanzer on molecular biology and biochemistry of [[collagens]]. However, when he moved to [[Public Health Research Institute]] in 1984, his focus shifted to molecular [[parasitology]] which remained the main theme of his researches thereafter. He returned to India to join [[National Institute of Malaria Research]] (erstwhile Malaria Research Centre) as a Pool Officer but his stay at NIMR lasted only six months until he was appointed as an associate professor at AIIMS Delhi where he established a laboratory for researches on molecular parasitology.<ref name="Indian fellow - Y D Sharma" /> Sharma continues at AIIMS as a professor since 1998 and heads the department of biotechnology<ref name="Department of Biotechnology">{{Cite web|url=http://www.aiims.edu/aiims/hospital%20zone/faculty_LIst_upto_10_10_14_15_11_14.pdf |title=Department of Biotechnology |date=2017 |publisher=AIIMS, Delhi}}</ref><ref name="Faculty profile">{{Cite web |url=http://103.13.242.103/~aiims/index.php?option=com_content&view=article&id=745&lang=en |title=Faculty profile |date=2017 |publisher=AIIMS Delhi |access-date=11 March 2017 |archive-date=9 January 2019 |archive-url=https://web.archive.org/web/20190109111019/http://103.13.242.103/~aiims/index.php?option=com_content&view=article&id=745&lang=en |url-status=dead }}</ref> while serving as the coordinator of Bioinformatics Centre of the institution.<ref name="Bioinformatics Centre">{{Cite web |url=http://btisnet.gov.in/SubDICaiims.asp |title=Bioinformatics Centre |date=2017 |publisher=AIIMS Delhi |access-date=2017-03-11 |archive-url=https://web.archive.org/web/20170312063024/http://btisnet.gov.in/SubDICaiims.asp |archive-date=2017-03-12 |url-status=dead }}</ref> In 2011, he also served as a part of the two-member committee constituted to investigate the plagiarism charges against one of the senior doctors of AIIMS.<ref name="AIIMS to probe plagiarism charges against senior doctor">{{Cite web |url=http://www.hindustantimes.com/delhi/aiims-to-probe-plagiarism-charges-against-senior-doctor/story-ABk1sRNY3Y6u4hEgnIcNdN.html |title=AIIMS to probe plagiarism charges against senior doctor |date=23 June 2011 |newspaper=Hindustan Times}}</ref>

== Legacy ==
[[File:Symptoms of Malaria.png|thumb|175px|left|Symptoms of malaria]]
During his days at [[Public Health Research Institute]], Sharma was successful in cloning the knob protein gene of ''[[Plasmodium falciparum]]'', one of the protozoan parasites causing malaria, in 1984.<ref name="Indian fellow - Y D Sharma" /> At AIIMS, he led a group of researchers who carried out molecular epidemiological studies of the parasites causing [[malaria]] and their studies widened the understanding of the parasites' resistance to [[chloroquine]] and [[Antifolate|antifolate drugs]].<ref name="BurmaChakravorty2011">{{cite book|author1=D. P. Burma|author2=Maharani Chakravorty|title=From Physiology and Chemistry to Biochemistry|url=https://books.google.com/books?id=4CaQ3-x3LXMC&pg=PA259|year=2011|publisher=Pearson Education India|isbn=978-81-317-3220-5|pages=259–}}</ref> Sharma is credited with the identification of ''P. falciparum'' strains in India, isolation of ''P. falciparum'' and ''[[Plasmodium vivax]]'', another non-cultivable protozoan parasite,<ref name="Research profile">{{Cite web |url=http://www.aiims.edu/en/2014-12-09-12-35-52/biotech_research.html |title=Research profile |date=2017 |publisher=AIIMS Delhi}}</ref> as well as the development of a [[genomic library]] of ''[[Plasmodium vivax]]''.<ref name="Indian fellow - Y D Sharma" /><ref name="Handbook of Shanti Swarup Bhatnagar Prize Winners">{{cite web | url=http://www.csirhrdg.res.in/ssb.pdf | title=Handbook of Shanti Swarup Bhatnagar Prize Winners | publisher=Council of Scientific and Industrial Research |page=71 |date=1999}}</ref> It was his group which reported the first incidence of malaria in humans caused by ''[[Plasmodium knowlesi]]'', a primate malarial parasite.<ref name="Faculty profile" /> These studies are reported to have relevance in developing [[immunotherapeutic]] reagents. Sharma 's research have been documented by way of several articles<ref name="On ResearchGate">{{Cite web |url=https://www.researchgate.net/profile/Yagya_Sharma4 |title=On ResearchGate |date=2017 }}</ref>{{Refn|group=note|Please see ''Selected bibliography'' section}} and the online repository of scientific articles of the [[Indian Academy of Sciences]] has listed a number of them.<ref name="Browse by Fellow">{{Cite web |url=http://repository.ias.ac.in/view/fellows/Sharma=3AYagya_Dutta=3A=3A.html |title=Browse by Fellow |date=2017 |publisher=Indian Academy of Sciences}}</ref> His work has been cited by many researchers<ref name="BakerBaker2001">{{cite book|author1=J. R. Baker|author2=John Robin Baker|author3=R. Muller, D. Rollinson|title=Advances in Parasitology|url=https://books.google.com/books?id=Iaf--6vvbkwC&pg=PA74|year=2001|publisher=Greenwood Publishing Group|isbn=978-0-12-031750-9|pages=74–}}</ref><ref name="SmithSimons2003">{{cite book|author1=H. John Smith|author2=Claire Simons|title=Proteinase and Peptidase Inhibition: Recent Potential Targets for Drug Development|url=https://books.google.com/books?id=JRSdVwX-K6wC&pg=PA454|date=2 September 2003|publisher=CRC Press|isbn=978-0-203-21917-1|pages=454–}}</ref><ref name="Strategies1991">{{cite book|author=Institute of Medicine (U.S.). Committee for the Study on Malaria Prevention and Control: Status Review and Alternative Strategies|title=Malaria: Obstacles and Opportunities|url=https://books.google.com/books?id=HUYrAAAAYAAJ&pg=PA115|date=1 January 1991|publisher=National Academies|pages=115–|isbn=9780309045278|id=NAP:13766}}</ref><ref>{{cite book|title=Advances in Parasitology|url=https://books.google.com/books?id=ZaTYMPCyK8EC&pg=PA145|date=13 February 1990|publisher=Academic Press|isbn=978-0-08-058075-3|pages=145–}}</ref> and he has mentored over 70 master's and doctoral students in their studies.<ref name="Faculty profile" />

== Awards and honors ==
The [[Council of Scientific and Industrial Research]] awarded Sharma the [[Shanti Swarup Bhatnagar Prize]], one of the highest Indian science awards, in 1994.<ref name="View Bhatnagar Awardees">{{cite web | url=http://ssbprize.gov.in/Content/AwardeeList.aspx | title=View Bhatnagar Awardees | publisher=Shanti Swarup Bhatnagar Prize | date=2016 | access-date=12 November 2016}}</ref><ref name="Medical Sciences">{{Cite web |url=http://www.csir.res.in/external/heads/career/award/BPRIZE/Medical_SCIENCES.htm |title=Medical Sciences |date=2017 |publisher=Council of Scientific and Industrial Research |url-status=dead |archive-url=https://web.archive.org/web/20130224074105/http://www.csir.res.in/External/Heads/career/award/BPRIZE/Medical_SCIENCES.htm |archive-date=2013-02-24 }}</ref> The [[National Academy of Sciences, India]] elected him as a fellow in 1993<ref name="NASI Year Book 2015">{{Cite web |url=http://www.nasi.org.in/Year%20Book%202015.pdf |title=NASI Year Book 2015 |date=2017 |publisher=National Academy of Sciences, India |access-date=11 March 2017 |archive-date=6 August 2015 |archive-url=https://web.archive.org/web/20150806211716/http://www.nasi.org.in/Year%20Book%202015.pdf |url-status=dead }}</ref><ref name="NASI fellows">{{Cite web |url=http://www.nasi.org.in/fellows.asp?RsFilter=S |title=NASI fellows |date=2017 |publisher=National Academy of Sciences, India |access-date=11 March 2017 |archive-date=16 March 2016 |archive-url=https://web.archive.org/web/20160316043224/http://nasi.org.in/fellows.asp?RsFilter=S |url-status=dead }}</ref> and he received Dr. [[M.O.T. Iyengar]] Memorial Prize of the [[Indian Council of Medical Research]] for his researches on malaria in 1997.<ref name="Faculty profile" /> Sharma became an elected fellow of the [[Indian Academy of Sciences]]<ref name="Fellow profile">{{Cite web |url=http://www.ias.ac.in/describe/fellow/Sharma,_Prof._Yagya_Dutta |title=Fellow profile |date=2017 |publisher=Indian Academy of Sciences}}</ref> in 2000 and the [[Indian National Science Academy]] 2006;<ref name="INSA Year Book 2016">{{Cite web |url=http://www.insaindia.res.in/pdf/YearBook_2016.pdf |title=INSA Year Book 2016 |date=2017 |publisher=Indian National Science Academy}}</ref> in between, he received the National Academy of Vector Borne Diseases Award in 2001.<ref name="National Academy of Vector Borne Diseases Award">{{Cite web |url=http://www.navbd.org/awards.html |title=National Academy of Vector Borne Diseases Award |date=2017 |publisher=National Academy of Vector Borne Diseases |access-date=11 March 2017 |archive-date=5 December 2019 |archive-url=https://web.archive.org/web/20191205032631/http://www.navbd.org/awards.html |url-status=dead }}</ref> He is a life member of the Indian Society for Malaria and Other Communicable Diseases<ref name="ISMOCD members">{{Cite web |url=http://ismocd.org/index.asp?page=finallist.htm |title=ISMOCD members |date=2017 |publisher=Indian Society for Malaria and Other Communicable Diseases}}</ref> and a member of [[New York Academy of Sciences]], [[American Society for Microbiology]], [[American Association for Advancement of Science]], and [[American Society of Tropical Medicine and Hygiene]].<ref name="Research profile" />

== Selected bibliography ==
* {{Cite journal |last=Mohammad Tauqeer Alam, Richa Agarwal, Yagya D. Sharma |title=Extensive heterozygosity at four microsatellite loci flanking Plasmodium vivax dihydrofolate reductase gene |journal=Molecular and Biochemical Parasitology |date=2007 |volume=153 |issue=2 |pages=178–185 |doi=10.1016/j.molbiopara.2007.03.003|pmid=17418906 }}
* {{Cite journal |vauthors=Thakur A, Alam MT, Sharma YD |title=Genetic diversity in the C-terminal 42 kDa region of merozoite surface protein-1 of Plasmodium vivax (PvMSP-1(42)) among Indian isolates |journal=Acta Trop. |date=2008 |volume=108 |issue=1 |pages=58–63 |doi=10.1016/j.actatropica.2008.08.011|pmid=18823930 }}
* {{Cite journal |vauthors=Alam MT, Bora H, Singh N, Sharma YD |title=High immunogenecity and erythrocyte-binding activity in the tryptophan-rich domain (TRD) of the 74-kDa Plasmodium vivax alanine-tryptophan-rich antigen (PvATRAg74) |journal=Vaccine |date=2008 |volume=26 |issue=31 |pages=3787–94 |doi=10.1016/j.vaccine.2008.05.059|pmid=18579264 }}
* {{Cite journal |vauthors=Ahmed A, Sharma YD |title=Ribozyme cleavage of Plasmodium falciparum gyrase A gene transcript affects the parasite growth |journal=Parasitol Res |date=2008 |volume=103 |issue=4 |pages=751–63 |doi=10.1007/s00436-008-1036-y|pmid=18523802 |s2cid=23199947 }}
* {{Cite journal |last=Hema Bora, Manoj K Das, Anwar Ahmed, Yagya D Sharma |title=Variations in the Mitochondrial DNA Markers in the Anopheles (Cellia) Sundaicus Population From the Andaman and Nicobar Islands, India |journal=Acta Trop |date=2009 |volume=112 |issue=2 |pages=120–124 |doi=10.1016/j.actatropica.2009.07.007|pmid=19595665 }}

== See also ==
{{Div col|colwidth=30em}}
* [[Malaria prophylaxis]]
* [[Antimalarial medication]]
{{div col end}}
{{portal|India|Medicine}}

== Notes ==
{{reflist|group=note|2}}

== References ==
{{reflist|30em}}

== External links ==
* {{Cite web |url=http://www.gettyimages.in/detail/news-photo/dr-yd-sharma-professor-and-head-of-department-of-news-photo/90558666#dr-yd-sharma-professor-and-head-of-department-of-biotechnology-all-picture-id90558666 |title=Y. D. Sharma |date=2017 |publisher=Getty Images}}
* {{Cite web |url=https://pubmed.ncbi.nlm.nih.gov/?term=Sharma%20YD%5BAuthor%5D&cauthor=true&cauthor_uid=18523802 |title=Y. D. Sharma |date=2017 |publisher= US National Library of Medicine |work=List of articles}}

== Further reading ==
* {{Cite web |url=http://www.indiamedicaltimes.com/2011/06/25/aiims-to-probe-plagiarism-charges-against-dr-muhammad-irshad/ |title=AIIMS to probe plagiarism charges against Dr Muhammad Irshad |date=25 June 2011 |publisher=India Medical Times |work=News report}}

{{SSBPST recipients in Medical Science}}

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{{DEFAULTSORT:Sharma, Y. D.}}
[[Category:Recipients of the Shanti Swarup Bhatnagar Award in Medical Science]]
[[Category:Indian molecular biologists]]
[[Category:Indian medical writers]]
[[Category:1951 births]]
[[Category:Living people]]
[[Category:Fellows of the Indian Academy of Sciences]]
[[Category:Fellows of the National Academy of Sciences, India]]
[[Category:Fellows of the Indian National Science Academy]]
[[Category:Dr. Bhimrao Ambedkar University alumni]]
[[Category:All India Institute of Medical Sciences, New Delhi alumni]]
[[Category:Academic staff of the All India Institute of Medical Sciences, New Delhi]]
[[Category:University of Connecticut alumni]]

Y. D. Sharma (professor) - Revision history

Udesign: creating initial bio basic info