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	<title>Vamsi Mootha - Revision history</title>
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	<updated>2026-09-25T11:26:19Z</updated>
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		<id>https://en.bharatpedia.org/w/index.php?title=Vamsi_Mootha&amp;diff=236884&amp;oldid=prev</id>
		<title>2601:184:497F:83C0:599A:6308:8047:8B97 at 16:13, 18 October 2021</title>
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		<updated>2021-10-18T16:13:05Z</updated>

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				&lt;td colspan=&quot;2&quot; style=&quot;background-color: #fff; color: #202122; text-align: center;&quot;&gt;← Older revision&lt;/td&gt;
				&lt;td colspan=&quot;2&quot; style=&quot;background-color: #fff; color: #202122; text-align: center;&quot;&gt;Revision as of 21:43, 18 October 2021&lt;/td&gt;
				&lt;/tr&gt;&lt;tr&gt;&lt;td colspan=&quot;2&quot; class=&quot;diff-lineno&quot; id=&quot;mw-diff-left-l23&quot;&gt;Line 23:&lt;/td&gt;
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&lt;tr&gt;&lt;td class=&quot;diff-marker&quot;&gt;&lt;/td&gt;&lt;td style=&quot;background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;&quot;&gt;&lt;div&gt;&amp;#039;&amp;#039;&amp;#039;Vamsi K. Mootha&amp;#039;&amp;#039;&amp;#039;  is an [[India|Indian]]-born [[United States|American]] physician-scientist and [[computational biology|computational biologist]]. He is an Investigator of the [[Howard Hughes Medical Institute]], Professor of Systems Biology and Medicine at [[Harvard Medical School]], and is based in the Department of Molecular Biology at [[Massachusetts General Hospital]]. He is also an Institute Member of the [[Broad Institute]].&amp;lt;ref&amp;gt;http://mootha.med.harvard.edu/members_vm.html Mootha&amp;#039;s biography&amp;lt;/ref&amp;gt;&lt;/div&gt;&lt;/td&gt;&lt;td class=&quot;diff-marker&quot;&gt;&lt;/td&gt;&lt;td style=&quot;background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;&quot;&gt;&lt;div&gt;&amp;#039;&amp;#039;&amp;#039;Vamsi K. Mootha&amp;#039;&amp;#039;&amp;#039;  is an [[India|Indian]]-born [[United States|American]] physician-scientist and [[computational biology|computational biologist]]. He is an Investigator of the [[Howard Hughes Medical Institute]], Professor of Systems Biology and Medicine at [[Harvard Medical School]], and is based in the Department of Molecular Biology at [[Massachusetts General Hospital]]. He is also an Institute Member of the [[Broad Institute]].&amp;lt;ref&amp;gt;http://mootha.med.harvard.edu/members_vm.html Mootha&amp;#039;s biography&amp;lt;/ref&amp;gt;&lt;/div&gt;&lt;/td&gt;&lt;/tr&gt;
&lt;tr&gt;&lt;td class=&quot;diff-marker&quot;&gt;&lt;/td&gt;&lt;td style=&quot;background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;&quot;&gt;&lt;br&gt;&lt;/td&gt;&lt;td class=&quot;diff-marker&quot;&gt;&lt;/td&gt;&lt;td style=&quot;background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;&quot;&gt;&lt;br&gt;&lt;/td&gt;&lt;/tr&gt;
&lt;tr&gt;&lt;td class=&quot;diff-marker&quot; data-marker=&quot;−&quot;&gt;&lt;/td&gt;&lt;td style=&quot;color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;&quot;&gt;&lt;div&gt;His research group has made major contributions to mitochondrial and &lt;del style=&quot;font-weight: bold; text-decoration: none;&quot;&gt;systems biology&lt;/del&gt;.  His group characterized the mammalian mitochondrial proteome&lt;del style=&quot;font-weight: bold; text-decoration: none;&quot;&gt;, identified &lt;/del&gt;dozens of mitochondrial disease genes&lt;del style=&quot;font-weight: bold; text-decoration: none;&quot;&gt;, and discovered &lt;/del&gt;the molecular &lt;del style=&quot;font-weight: bold; text-decoration: none;&quot;&gt;identity &lt;/del&gt;of the mitochondrial calcium uniporter.  His team has also made the unexpected discovery that in animal models, low oxygen can &lt;del style=&quot;font-weight: bold; text-decoration: none;&quot;&gt;prevent and &lt;/del&gt;alleviate mitochondrial disease.  As a postdoctoral fellow he developed [[Gene Set Enrichment Analysis]], an algorithm that is widely used in genomics and has been implemented into a popular software tool.&lt;/div&gt;&lt;/td&gt;&lt;td class=&quot;diff-marker&quot; data-marker=&quot;+&quot;&gt;&lt;/td&gt;&lt;td style=&quot;color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;&quot;&gt;&lt;div&gt;His research group has made major contributions to mitochondrial &lt;ins style=&quot;font-weight: bold; text-decoration: none;&quot;&gt;biology &lt;/ins&gt;and &lt;ins style=&quot;font-weight: bold; text-decoration: none;&quot;&gt;genomics&lt;/ins&gt;.  His group characterized the mammalian mitochondrial proteome &lt;ins style=&quot;font-weight: bold; text-decoration: none;&quot;&gt;and applied it to identify &lt;/ins&gt;dozens of mitochondrial disease genes&lt;ins style=&quot;font-weight: bold; text-decoration: none;&quot;&gt;.  His team used integrative genomics to identify &lt;/ins&gt;the molecular &lt;ins style=&quot;font-weight: bold; text-decoration: none;&quot;&gt;components &lt;/ins&gt;of the mitochondrial calcium uniporter.  His team has also made the unexpected discovery that in animal models, low oxygen can alleviate mitochondrial disease.  As a postdoctoral fellow he developed [[Gene Set Enrichment Analysis]], an algorithm that is widely used in genomics and has been implemented into a popular software tool.&lt;/div&gt;&lt;/td&gt;&lt;/tr&gt;
&lt;tr&gt;&lt;td class=&quot;diff-marker&quot;&gt;&lt;/td&gt;&lt;td style=&quot;background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;&quot;&gt;&lt;br&gt;&lt;/td&gt;&lt;td class=&quot;diff-marker&quot;&gt;&lt;/td&gt;&lt;td style=&quot;background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;&quot;&gt;&lt;br&gt;&lt;/td&gt;&lt;/tr&gt;
&lt;tr&gt;&lt;td class=&quot;diff-marker&quot; data-marker=&quot;−&quot;&gt;&lt;/td&gt;&lt;td style=&quot;color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;&quot;&gt;&lt;div&gt;He is a  2004 recipient of the [[MacArthur Fellows Program|Macarthur Foundation &quot;genius award&quot;]].  He received the 2008 Daland Prize from the [[American Philosophical Society]] and a 2014 [[Padma Shri]] Award from the [[Republic of India]], the fourth highest civilian award given by the Indian government.&amp;lt;ref&amp;gt;[http://www.thehindu.com/news/national/padma-awards-for-7-persons-under-nri-pio-foreign-category/article5618199.ece Padma awards for 7 persons under NRI, PIO, foreign category - The Hindu&amp;lt;!-- Bot generated title --&amp;gt;]&amp;lt;/ref&amp;gt;&amp;lt;ref&amp;gt;{{Cite web|url=http://www.americanbazaaronline.com/2014/01/27/five-eminent-personalities-us-get-padma-awards-3-indian-americans/|title = Five eminent personalities from the US get Padma awards, 3 of them Indian Americans|date = 27 January 2014}}&amp;lt;/ref&amp;gt;&amp;lt;ref&amp;gt;[http://www.broad.mit.edu/about/bios/bio-mootha.html Vamsi Mootha | Broad Institute of MIT and Harvard&amp;lt;!-- Bot generated title --&amp;gt;]&amp;lt;/ref&amp;gt;&amp;lt;ref&amp;gt;[http://jem.rupress.org/cgi/content/full/205/6/1248 Vamsi Mootha: Taking an inventory of mitochondria&amp;lt;!-- Bot generated title --&amp;gt;]&amp;lt;/ref&amp;gt;  He was elected to the United States National Academy of Sciences in 2014.  He also served on the Life Sciences jury for the [[Infosys Prize]] in 2017.&lt;/div&gt;&lt;/td&gt;&lt;td class=&quot;diff-marker&quot; data-marker=&quot;+&quot;&gt;&lt;/td&gt;&lt;td style=&quot;color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;&quot;&gt;&lt;div&gt;He is a  2004 recipient of the [[MacArthur Fellows Program|Macarthur Foundation &quot;genius award&quot;]].  He received the 2008 Daland Prize from the [[American Philosophical Society]] and a 2014 [[Padma Shri]] Award from the [[Republic of India]], the fourth highest civilian award given by the Indian government.&amp;lt;ref&amp;gt;[http://www.thehindu.com/news/national/padma-awards-for-7-persons-under-nri-pio-foreign-category/article5618199.ece Padma awards for 7 persons under NRI, PIO, foreign category - The Hindu&amp;lt;!-- Bot generated title --&amp;gt;]&amp;lt;/ref&amp;gt;&amp;lt;ref&amp;gt;{{Cite web|url=http://www.americanbazaaronline.com/2014/01/27/five-eminent-personalities-us-get-padma-awards-3-indian-americans/|title = Five eminent personalities from the US get Padma awards, 3 of them Indian Americans|date = 27 January 2014}}&amp;lt;/ref&amp;gt;&amp;lt;ref&amp;gt;[http://www.broad.mit.edu/about/bios/bio-mootha.html Vamsi Mootha | Broad Institute of MIT and Harvard&amp;lt;!-- Bot generated title --&amp;gt;]&amp;lt;/ref&amp;gt;&amp;lt;ref&amp;gt;[http://jem.rupress.org/cgi/content/full/205/6/1248 Vamsi Mootha: Taking an inventory of mitochondria&amp;lt;!-- Bot generated title --&amp;gt;]&amp;lt;/ref&amp;gt;  He was elected to the United States National Academy of Sciences in 2014 &lt;ins style=&quot;font-weight: bold; text-decoration: none;&quot;&gt;and the National Academy of Medicine in 2021&lt;/ins&gt;.  He also served on the Life Sciences jury for the [[Infosys Prize]] in 2017.&lt;/div&gt;&lt;/td&gt;&lt;/tr&gt;
&lt;tr&gt;&lt;td class=&quot;diff-marker&quot;&gt;&lt;/td&gt;&lt;td style=&quot;background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;&quot;&gt;&lt;br&gt;&lt;/td&gt;&lt;td class=&quot;diff-marker&quot;&gt;&lt;/td&gt;&lt;td style=&quot;background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;&quot;&gt;&lt;br&gt;&lt;/td&gt;&lt;/tr&gt;
&lt;tr&gt;&lt;td class=&quot;diff-marker&quot; data-marker=&quot;−&quot;&gt;&lt;/td&gt;&lt;td style=&quot;color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;&quot;&gt;&lt;div&gt;Mootha graduated from Kelly High School in Beaumont, Texas. &lt;del style=&quot;font-weight: bold; text-decoration: none;&quot;&gt;Mootha &lt;/del&gt;received his [[Bachelor of Science|BS]] in Mathematical and Computational Science from [[Stanford University]] and his M.D. from [[Harvard University]].  He completed his internship and residency in internal medicine at [[Brigham and Women&#039;s Hospital]] in Boston, and then pursued postdoctoral training with [[Eric Lander]] at the Whitehead Institute/MIT [[Center for Genome Research]].&amp;lt;ref&amp;gt;[http://mootha.med.harvard.edu/ Mootha Laboratory&amp;lt;!-- Bot generated title --&amp;gt;]&amp;lt;/ref&amp;gt;&lt;/div&gt;&lt;/td&gt;&lt;td class=&quot;diff-marker&quot; data-marker=&quot;+&quot;&gt;&lt;/td&gt;&lt;td style=&quot;color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;&quot;&gt;&lt;div&gt;Mootha graduated from Kelly High School in Beaumont, Texas. &lt;ins style=&quot;font-weight: bold; text-decoration: none;&quot;&gt;He &lt;/ins&gt;received his [[Bachelor of Science|BS]] in Mathematical and Computational Science from [[Stanford University]] and his M.D. from [[Harvard University]].  He completed his internship and residency in internal medicine at [[Brigham and Women&#039;s Hospital]] in Boston, and then pursued postdoctoral training with [[Eric Lander]] at the Whitehead Institute/MIT [[Center for Genome Research]].&amp;lt;ref&amp;gt;[http://mootha.med.harvard.edu/ Mootha Laboratory&amp;lt;!-- Bot generated title --&amp;gt;]&amp;lt;/ref&amp;gt;&lt;/div&gt;&lt;/td&gt;&lt;/tr&gt;
&lt;tr&gt;&lt;td class=&quot;diff-marker&quot;&gt;&lt;/td&gt;&lt;td style=&quot;background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;&quot;&gt;&lt;br&gt;&lt;/td&gt;&lt;td class=&quot;diff-marker&quot;&gt;&lt;/td&gt;&lt;td style=&quot;background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;&quot;&gt;&lt;br&gt;&lt;/td&gt;&lt;/tr&gt;
&lt;tr&gt;&lt;td class=&quot;diff-marker&quot;&gt;&lt;/td&gt;&lt;td style=&quot;background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;&quot;&gt;&lt;div&gt;==References==&lt;/div&gt;&lt;/td&gt;&lt;td class=&quot;diff-marker&quot;&gt;&lt;/td&gt;&lt;td style=&quot;background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;&quot;&gt;&lt;div&gt;==References==&lt;/div&gt;&lt;/td&gt;&lt;/tr&gt;
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{{Infobox person&lt;br /&gt;
| name               = Vamsi K. Mootha&lt;br /&gt;
| image              = &lt;br /&gt;
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| birth_name         = &lt;br /&gt;
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| birth_place        = [[Kakinada]], [[Andhra Pradesh]], [[India]]&lt;br /&gt;
| citizenship        = United States&lt;br /&gt;
| education          = M.D.&lt;br /&gt;
| alma_mater         = [[Stanford University]]&amp;lt;br&amp;gt;[[Harvard–MIT Division of Health Sciences and Technology]]&lt;br /&gt;
| occupation         = Professor&lt;br /&gt;
| employer           = [[Howard Hughes Medical Institute]]&amp;lt;br&amp;gt;[[Massachusetts General Hospital]]&amp;lt;br&amp;gt;[[Harvard Medical School]]&lt;br /&gt;
| salary             = &lt;br /&gt;
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| spouse             = &lt;br /&gt;
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&lt;br /&gt;
&amp;#039;&amp;#039;&amp;#039;Vamsi K. Mootha&amp;#039;&amp;#039;&amp;#039;  is an [[India|Indian]]-born [[United States|American]] physician-scientist and [[computational biology|computational biologist]]. He is an Investigator of the [[Howard Hughes Medical Institute]], Professor of Systems Biology and Medicine at [[Harvard Medical School]], and is based in the Department of Molecular Biology at [[Massachusetts General Hospital]]. He is also an Institute Member of the [[Broad Institute]].&amp;lt;ref&amp;gt;http://mootha.med.harvard.edu/members_vm.html Mootha&amp;#039;s biography&amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
His research group has made major contributions to mitochondrial and systems biology.  His group characterized the mammalian mitochondrial proteome, identified dozens of mitochondrial disease genes, and discovered the molecular identity of the mitochondrial calcium uniporter.  His team has also made the unexpected discovery that in animal models, low oxygen can prevent and alleviate mitochondrial disease.  As a postdoctoral fellow he developed [[Gene Set Enrichment Analysis]], an algorithm that is widely used in genomics and has been implemented into a popular software tool.&lt;br /&gt;
&lt;br /&gt;
He is a  2004 recipient of the [[MacArthur Fellows Program|Macarthur Foundation &amp;quot;genius award&amp;quot;]].  He received the 2008 Daland Prize from the [[American Philosophical Society]] and a 2014 [[Padma Shri]] Award from the [[Republic of India]], the fourth highest civilian award given by the Indian government.&amp;lt;ref&amp;gt;[http://www.thehindu.com/news/national/padma-awards-for-7-persons-under-nri-pio-foreign-category/article5618199.ece Padma awards for 7 persons under NRI, PIO, foreign category - The Hindu&amp;lt;!-- Bot generated title --&amp;gt;]&amp;lt;/ref&amp;gt;&amp;lt;ref&amp;gt;{{Cite web|url=http://www.americanbazaaronline.com/2014/01/27/five-eminent-personalities-us-get-padma-awards-3-indian-americans/|title = Five eminent personalities from the US get Padma awards, 3 of them Indian Americans|date = 27 January 2014}}&amp;lt;/ref&amp;gt;&amp;lt;ref&amp;gt;[http://www.broad.mit.edu/about/bios/bio-mootha.html Vamsi Mootha | Broad Institute of MIT and Harvard&amp;lt;!-- Bot generated title --&amp;gt;]&amp;lt;/ref&amp;gt;&amp;lt;ref&amp;gt;[http://jem.rupress.org/cgi/content/full/205/6/1248 Vamsi Mootha: Taking an inventory of mitochondria&amp;lt;!-- Bot generated title --&amp;gt;]&amp;lt;/ref&amp;gt;  He was elected to the United States National Academy of Sciences in 2014.  He also served on the Life Sciences jury for the [[Infosys Prize]] in 2017.&lt;br /&gt;
&lt;br /&gt;
Mootha graduated from Kelly High School in Beaumont, Texas. Mootha received his [[Bachelor of Science|BS]] in Mathematical and Computational Science from [[Stanford University]] and his M.D. from [[Harvard University]].  He completed his internship and residency in internal medicine at [[Brigham and Women&amp;#039;s Hospital]] in Boston, and then pursued postdoctoral training with [[Eric Lander]] at the Whitehead Institute/MIT [[Center for Genome Research]].&amp;lt;ref&amp;gt;[http://mootha.med.harvard.edu/ Mootha Laboratory&amp;lt;!-- Bot generated title --&amp;gt;]&amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
==References==&lt;br /&gt;
{{Reflist}}&lt;br /&gt;
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{{Authority control}}&lt;br /&gt;
{{Padma Shri Award Recipients in Medicine}}&lt;br /&gt;
{{DEFAULTSORT:Mootha, Vamsi}}&lt;br /&gt;
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[[Category:MacArthur Fellows]]&lt;br /&gt;
[[Category:American people of Telugu descent]]&lt;br /&gt;
[[Category:Systems biologists]]&lt;br /&gt;
[[Category:Stanford University alumni]]&lt;br /&gt;
[[Category:Harvard Medical School alumni]]&lt;br /&gt;
[[Category:American people of Indian descent]]&lt;br /&gt;
[[Category:Harvard Medical School faculty]]&lt;br /&gt;
[[Category:People from Beaumont, Texas]]&lt;br /&gt;
[[Category:Howard Hughes Medical Investigators]]&lt;br /&gt;
[[Category:Scientists from Andhra Pradesh]]&lt;br /&gt;
[[Category:Massachusetts General Hospital faculty]]&lt;br /&gt;
[[Category:Recipients of the Padma Shri in medicine]]&lt;br /&gt;
[[Category:People from Kakinada]]&lt;br /&gt;
[[Category:Members of the United States National Academy of Sciences]]&lt;/div&gt;</summary>
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