https://en.bharatpedia.org/w/index.php?action=history&feed=atom&title=Suresh_H._MoolgavkarSuresh H. Moolgavkar - Revision history2026-08-18T11:32:27ZRevision history for this page on the wikiMediaWiki 1.43.6https://en.bharatpedia.org/w/index.php?title=Suresh_H._Moolgavkar&diff=538573&oldid=prevJameshowlett179011: added new page needs work2024-09-30T14:37:12Z<p>added new page needs work</p>
<p><b>New page</b></p><div>{{Use dmy dates|date=May 2018}}<br />
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{{Infobox scientist<br />
| name = Suresh H. Moolgavkar <br />
| image = WikiSuresh.jpg<br />
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| birth_date = {{Birth date and age|df=yes|1943|1|3}}<br />
| birth_place = [[Bombay, India]]<br />
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| fields = [[Epidemiology]], [[Mathematics]]<br />
| workplaces = [[University of Washington]], [[Fred Hutchinson Cancer Research Center]]<br />
| alma_mater = [[Johns Hopkins University]]<br />
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| known_for = Two-stage Clonal Expansion (TSCE) Model of Carcinogenesis<br />
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'''Suresh H. Moolgavkar''' (born 3 January 1943) is an Indian mathematician and epidemiologist who was at the University of Washington and the Fred Hutchinson Cancer Research Center in Seattle. He is a Senior Fellow and Research Scientist at Exponent, a consulting firm.<ref>{{Cite web |title=Suresh H. Moolgavkar |url=https://www.exponent.com/professionals/m/moolgavkar-suresh-h |access-date=2022-12-23 |website=www.exponent.com |date=3 November 2022 |language=en-us}}</ref> Among his many scientific contributions is the development of the two-stage clonal expansion (TSCE) model of carcinogenesis, also known as the Moolgavkar-Venzon-Knudson (MVK) model, a stochastic cell-level description of carcinogenesis based on [[Alfred G. Knudson]]’s two-hit hypothesis.<ref>{{cite journal|last=Knudson|first=Alfred G Jr.|title=Mutation and cancer: Statistical study of retinoblastoma|journal=Proc Natl Acad Sci USA|year=1971|volume=68|issue=4|pages=820–823|pmid=5279523|doi=10.1073/pnas.68.4.820|pmc=389051|bibcode=1971PNAS...68..820K|doi-access=free}}</ref> In its original development the TSCE model<ref>{{cite journal|last=Moolgavkar|first=Suresh H.|author2=Knudson AG |title=Mutation and cancer: A model for human carcinogenesis|journal=JNCI|year=1981|volume=66|issue=6|pages=1037–1052|pmid=6941039|doi=10.1093/jnci/66.6.1037}}</ref> represents tumor initiation as the first hit, followed by cell proliferation (clonal expansion) and malignant transformation as the second hit. It has been interpreted as describing the initiation-promotion-progression sequence observed in chemical carcinogenesis and has been applied widely for the analysis of both experimental and epidemiological data for purposes of quantitative risk assessment.<br />
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==References==<br />
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[[Category:1943 births]]<br />
[[Category:Living people]]<br />
[[Category:20th-century Indian mathematicians]]<br />
[[Category:20th-century Indian medical doctors]]<br />
[[Category:20th-century American mathematicians]]<br />
[[Category:American epidemiologists]]<br />
[[Category:Cancer researchers]]<br />
[[Category:Medical doctors from Mumbai]]<br />
[[Category:Indian medical researchers]]<br />
[[Category:Indian emigrants to the United States]]<br />
[[Category:Fred Hutchinson Cancer Research Center people]]<br />
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