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	<title>Sandalwood oil - Revision history</title>
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		<title>FredricKeeton9: Made new data.</title>
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		<summary type="html">&lt;p&gt;Made new data.&lt;/p&gt;
&lt;p&gt;&lt;b&gt;New page&lt;/b&gt;&lt;/p&gt;&lt;div&gt;{{Short description|Essential oil}}&lt;br /&gt;
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[[Image:SandalwoodEssOil.png|thumb|right|200px|A glass vial containing pure Sandalwood Essential Oil]]&lt;br /&gt;
{{Use dmy dates|date=March 2021}}&lt;br /&gt;
&amp;#039;&amp;#039;&amp;#039;Sandalwood oil&amp;#039;&amp;#039;&amp;#039; is an [[essential oil]] obtained from the [[steam distillation]] of chips and billets cut from the heartwood of various species of [[sandalwood]] trees, mainly &amp;#039;&amp;#039;[[Santalum album]]&amp;#039;&amp;#039; (Indian sandalwood)&amp;lt;ref name=Kapoor2001/&amp;gt; and &amp;#039;&amp;#039;[[Santalum spicatum]]&amp;#039;&amp;#039; (Australian sandalwood).&amp;lt;ref name=acne-soe/&amp;gt;&lt;br /&gt;
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Sandalwood oil is used in [[perfume]]s, [[cosmetics]], sacred [[unguent]]s, and as a mild food flavouring.&amp;lt;ref name=Kapoor2001&amp;gt;{{ cite book | author = Kapoor LD | title = Handbook of Ayurvedic Medicinal Plants | volume = 2 | series = Herbal Reference Library Series | publisher = CRC Press | location = Boca Raton, Florida | year = 2001 | isbn = 978-0-8493-2929-6 }}&amp;lt;/ref&amp;gt;&lt;br /&gt;
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==Main constituents==&lt;br /&gt;
Sandalwood oil contains more than 90% [[sesquiterpene|sesquiterpenic]] [[Alcohol (chemistry)|alcohol]]s of which 50–60% is the [[tricyclic]] [[α-Santalol|α-santalol]]. [[β-Santalol]] comprises 20–25%.&amp;lt;ref name=acne-soe&amp;gt;{{cite web |url=http://scienceofacne.com/sandalwood-essential-oil/ |title=Sandalwood Essential Oil |year=2015 |website=The Science of Acne |archive-url=https://web.archive.org/web/20150224053817/http://thescienceofacne.com/sandalwood/ |archive-date=2015-02-24  }}&amp;lt;/ref&amp;gt;&amp;lt;ref&amp;gt;{{ cite journal |vauthors=Krotz A, Helmchen G | title = Total Syntheses, Optical Rotations and Fragrance Properties of Sandalwood Constituents: (−)-(&amp;#039;&amp;#039;Z&amp;#039;&amp;#039;)- and (−)-(&amp;#039;&amp;#039;E&amp;#039;&amp;#039;)-β-Santalol and Their Enantiomers, &amp;#039;&amp;#039;ent&amp;#039;&amp;#039;-β-Santalene | journal = Liebigs Ann Chem | year = 1994 | volume = 1994 | issue = 6 | pages = 601–609 | doi = 10.1002/jlac.199419940610 }}&amp;lt;/ref&amp;gt;&lt;br /&gt;
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The composition of the oil will depend on the species, region grown, age of tree,&amp;lt;ref name=acne-soe/&amp;gt; and possibly the season of harvest and details of the extraction process used.&lt;br /&gt;
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Current [[International Organization for Standardization]] (ISO) standards for &amp;#039;&amp;#039;S. album&amp;#039;&amp;#039; oil are 41–55% α-santalol and 16–24% β–santalol (ISO 3518: 2002E).&amp;lt;ref&amp;gt;{{cite web |url=http://www.fpc.wa.gov.au/content_migration/about_us/media/releases/20060328B.aspx |title=Preliminary oil results from a 14-year-old Indian Sandalwood (Santalum album) plantation at Kununurra, WA |date=2006-03-28  |website=Forest Products Commission |archive-url=https://web.archive.org/web/20160304180731/http://www.fpc.wa.gov.au/content_migration/about_us/media/releases/20060328B.aspx |archive-date=2016-03-04 }}&amp;lt;/ref&amp;gt;&lt;br /&gt;
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==Traditional uses==&lt;br /&gt;
Due to its highly coveted fragrance, the essential oil produced from sandalwood is often used in [[aromatherapy]], and is also added to soaps, [[cosmetics]] and perfumes (usually combined with floral, resinous and spicy notes)&amp;lt;ref&amp;gt;{{Cite web |title=Сандаловое эфирное масло (Oleum Santali) |url=https://oleumsantali.ru/ |access-date=2026-01-15 |website=oleumsantali.ru}}&amp;lt;/ref&amp;gt;. It is used in [[Ayurvedic]] medicine for the treatment of both [[Somatic nervous system|somatic]] and mental disorders, including common colds, bronchitis, fever, [[urinary tract infection]]s, and inflammation.&amp;lt;ref name=pmid16783696/&amp;gt; A study investigating the effects of inhalation of East Indian sandalwood oil and its main compound, α-santalol, on human physiological parameters found that the compounds elevated pulse rate, skin conductance, and [[systolic blood pressure]].&amp;lt;ref name=pmid16783696&amp;gt;{{cite journal | last1 = Heuberger | first1 = E | last2 = Hongratanaworakit | first2 = T | last3 = Buchbauer | first3 = G | title = East Indian Sandalwood and alpha-santalol odor increase physiological and self-rated arousal in humans | journal = Planta Medica | year = 2006 | volume = 72 | issue = 9 | pages = 792–800 | doi = 10.1055/s-2006-941544 | pmid = 16783696 }}&amp;lt;/ref&amp;gt; &lt;br /&gt;
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There is also religious significance associated with sandalwood oil and it is used in many different religions around the world, including [[Hinduism]], [[Jainism]], [[Buddhism]], and [[Zoroastrianism]].{{cn|date=July 2022}}&lt;br /&gt;
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==Production==&lt;br /&gt;
{{See also |Sandalwood#Production|Sandalwood#Distillation}}&lt;br /&gt;
The oil is distilled from the wood of the entire tree including stump and roots.&amp;lt;ref&amp;gt;{{cite web |author=Tony Page |author2=Hanington Tate |author3=Joseph Tungon |author4=Michael Tabi |author5=Phyllis Kamasteia |url= http://aciar.gov.au/files/node/14881/mn151_vanuatu_sandalwood_growers_guide_for_san_46020.pdf |title= Vanuatu sandalwood: growers&amp;#039; guide for sandalwood production in Vanuatu |publisher= Australian Centre for International Agricultural Research |page= 47 |year= 2012 |access-date= 9 May 2015 |archive-url= https://web.archive.org/web/20160305022931/http://aciar.gov.au/files/node/14881/mn151_vanuatu_sandalwood_growers_guide_for_san_46020.pdf |archive-date= 2016-03-05 }}&amp;lt;/ref&amp;gt; Australian sandalwood (&amp;#039;&amp;#039;S. spicatum&amp;#039;&amp;#039;) is unique in that the white [[sapwood (wood)|sapwood]] does not require removal before distilling the oil, while Indian Sandalwood (&amp;#039;&amp;#039;S. album&amp;#039;&amp;#039;) does require removal of the sapwood prior to distillation.&amp;lt;ref name=waspfaq&amp;gt;{{cite web | title=Frequently Asked Questions | website=WA Sandalwood Plantations | url=https://www.wasandalwood.com/faq | access-date=19 September 2020}}&amp;lt;/ref&amp;gt;&lt;br /&gt;
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== Fragrance  ==&lt;br /&gt;
Sandalwood oil is used extensively for its woody-floral scent. Sandalwood oil can also, under certain conditions, have a creamy or even pickled aroma.&amp;lt;ref&amp;gt;{{Cite web |title=Парфюмерный словарь - Термины из парфюмерии. |url=https://slovarparfum.ru/ |access-date=2025-04-15 |website=slovarparfum.ru}}&amp;lt;/ref&amp;gt; It pairs well with other wood or floral scents such as violet, rose, tuberose, clove, and oakmoss.&amp;lt;ref name=&amp;quot;:0&amp;quot;&amp;gt;{{Cite journal|author1=Burdock, George A |author2=Carabin, Ioana G |date=Summer 2007|title=Safety assessment of sandalwood oil|journal=Food and Chemical Toxicology|volume=46|issue=2|pages=421–432|doi=10.1016/j.fct.2007.09.092|pmid=17980948}}&amp;lt;/ref&amp;gt; But since the wood is so rare and expensive, cosmetic companies use synthetic substitutes of similar structure and scent.&lt;br /&gt;
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There are several synthetic [[odorants]] with odor similar to sandalwood oil, used as lower-cost alternatives for perfumes, emollients, and skin cleaning agents.  Common synthetic substitutes include [[Bacdanlol]], Brahmanol, [[Ebanol]], [[Firsantol]], Sandalore, and [[Sandaxol]].&amp;lt;ref&amp;gt;{{cite journal | last=Cancellieri | first=Maria C. | last2=Maggioni | first2=Davide | last3=Di Maio | first3=Lorenzo | last4=Fiorito | first4=Daniele | last5=Brenna | first5=Elisabetta | last6=Parmeggiani | first6=Fabio | last7=Gatti | first7=Francesco G. | title=Biocatalytic approaches for a more sustainable synthesis of sandalwood fragrances | journal=Green Chemistry | volume=26 | issue=10 | date=2024 | issn=1463-9262 | doi=10.1039/D4GC00746H | doi-access=free | pages=6150–6159 | url=https://pubs.rsc.org/en/content/articlepdf/2024/gc/d4gc00746h| hdl=11311/1265004 | hdl-access=free }}&amp;lt;/ref&amp;gt;&lt;br /&gt;
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Two of these, [[Sandalore]] and [[Brahmanol]], have been found to be [[agonist]]s of the cutaneous [[olfactory receptor]] [[OR2AT4]], with potential therapeutic benefits for wound healing. Natural sandalwood oil, and other synthetic sandalwood odorants, did not have the same effect.&amp;lt;ref&amp;gt;{{cite journal | last=Busse | first=Daniela | last2=Kudella | first2=Philipp | last3=Grüning | first3=Nana-Maria | last4=Gisselmann | first4=Günter | last5=Ständer | first5=Sonja | last6=Luger | first6=Thomas | last7=Jacobsen | first7=Frank | last8=Steinsträßer | first8=Lars | last9=Paus | first9=Ralf | last10=Gkogkolou | first10=Paraskevi | last11=Böhm | first11=Markus | last12=Hatt | first12=Hanns | last13=Benecke | first13=Heike | title=A Synthetic Sandalwood Odorant Induces Wound-Healing Processes in Human Keratinocytes via the Olfactory Receptor OR2AT4 | journal=Journal of Investigative Dermatology | volume=134 | issue=11 | date=2014 | doi=10.1038/jid.2014.273 | doi-access=free| pmid = 24999593 | pages=2823–2832 | url=http://www.jidonline.org/article/S0022202X15365386/pdf}}&amp;lt;/ref&amp;gt;&amp;lt;ref&amp;gt;[https://www.newscientist.com/article/dn25865-skins-ability-to-smell-seems-to-help-it-heal-itself/ New Scientist magazine, Skin&amp;#039;s ability to &amp;#039;smell&amp;#039; seems to help it heal itself, 8 July 2014]&amp;lt;/ref&amp;gt;&lt;br /&gt;
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== Safety ==&lt;br /&gt;
There hasn&amp;#039;t been extensive research conducted on the safety of sandalwood oil. But because there haven&amp;#039;t been any significant adverse effects documented in [[scientific literature]], it continues to be used cosmetically and in food. A few studies were found to identify sandalwood oil&amp;#039;s potential toxic effects, but it was determined to be safe at the present levels that the oil is used in food as flavorings.&lt;br /&gt;
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==See also==&lt;br /&gt;
* [[Isobornyl cyclohexanol]], a synthetic sandalwood oil&lt;br /&gt;
* [[Sandalore]], a synthetic sandalwood odorant&lt;br /&gt;
* [[Mysore Sandalwood Oil]]&lt;br /&gt;
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==References==&lt;br /&gt;
{{reflist}}&lt;br /&gt;
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{{Wood products}}&lt;br /&gt;
{{Non-timber forest products}}&lt;br /&gt;
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[[Category:Essential oils]]&lt;br /&gt;
[[Category:Santalum|*]]&lt;/div&gt;</summary>
		<author><name>FredricKeeton9</name></author>
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