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{{Short description|Indian biochemist, virologist and professor}}
{{Use dmy dates|date=February 2019}}
{{Use Indian English|date=February 2019}}
{{Infobox scientist
| name = P. N. Rangarajan
| image =
| alt =
| caption =
| birth_date = {{Birth date and age|df=yes|1963|4|15}}
| birth_place = [[Bengaluru]], [[Karnataka]], India
| death_date =
| death_place =
| fields = {{ublist | [[Biochemistry]] | [[Virology]] }}
| workplaces = {{ublist | [[Howard Hughes Medical Institute]] | [[Indian Institute of Science]] }}
| alma_mater = {{ublist | [[Indian Institute of Science]] | [[Salk Institute for Biological Studies]] }}
| doctoral_advisor =
| doctoral_students =
| known_for = Studies on [[eukaryotic]] [[gene expression]]
| awards = {{ublist| 2001 [[National Bioscience Award for Career Development|N-BIOS Prize]] | 2007 [[Shanti Swarup Bhatnagar Prize]] }}
}}
'''Pundi Narasimhan Rangarajan''' (born 15 April 1963) is an Indian biochemist, virologist and a professor at the department of biochemistry of the [[Indian Institute of Science]]. Prof Rangarajan is currently the Chairman of the Department of Biochemistry at Indian Institute of Science. Known for his research on [[eukaryotic]] [[gene expression]], Rangarajan is an elected fellow of all the three major Indian science academies viz. [[National Academy of Sciences, India]], [[Indian Academy of Sciences]] and [[Indian National Science Academy]]. The [[Council of Scientific and Industrial Research]], the apex agency of the Government of India for scientific research, awarded him the [[Shanti Swarup Bhatnagar Prize for Science and Technology]], one of the highest Indian science awards for his contributions to Medical Sciences in 2007.<ref name="View Bhatnagar Awardees">{{cite web | url=http://ssbprize.gov.in/Content/AwardeeList.aspx | title=View Bhatnagar Awardees | publisher=Shanti Swarup Bhatnagar Prize | date=2016 | access-date=12 November 2016}}</ref>{{Refn|group=note|Long link - please select award year to see details}}

== Biography ==
[[File:IISc Main Building.jpg|thumb|235px|Indian Institute of Science]]
P. N. Rangarajan, born in [[Bengaluru]] in the south Indian state of [[Karnataka]], secured a PhD from the [[Indian Institute of Science]] (IISc) in 1989 and did his post doctoral work at [[Salk Institute for Biological Studies]] during 1990-92.<ref name="Faculty Profile">{{Cite web |url=http://biochem.iisc.ernet.in/pnrangarajan.php |title=Faculty Profile |date=2017 |publisher=Indian Institute of Science |access-date=1 April 2017 |archive-date=4 April 2020 |archive-url=https://web.archive.org/web/20200404123406/http://biochem.iisc.ernet.in/pnrangarajan.php |url-status=dead }}</ref> After serving [[Howard Hughes Medical Institute]] as a research associate for a year, he returned to India to join IISc at the department of biochemistry in 1993 where he is a professor. At IISc, he has been carrying out research on how [[neurotropic virus]]es induce changes in [[eukaryotic]] [[gene expression]] in humans.<ref name="Brief Profile of the Awardee">{{Cite web |url=http://ssbprize.gov.in/Content/Detail.aspx?AID=32 |title=Brief Profile of the Awardee |date=2017 |publisher=Shanti Swarup Bhatnagar Prize}}</ref> He leads a team of scientists engaged in the studies of ''[[Pichia pastoris]]'', a [[methylotrophic]] [[yeast]] species, with regard to its [[transcription factors]] and the regulation of carbon metabolism.<ref name="Professor Department of Biochemistry">{{Cite book |url=http://bio.iisc.ac.in/?q=faculty/p-n-rangarajan |title=Professor Department of Biochemistry |date=2017 |publisher=Indian Institute of Science |access-date=1 April 2017 |archive-date=20 February 2019 |archive-url=https://web.archive.org/web/20190220002808/http://bio.iisc.ac.in/?q=faculty%2Fp-n-rangarajan |url-status=dead }}</ref> He has also done extensive work on vaccine development against infectious diseases such as [[rabies]], [[hepatitis B]] and [[Japanese encephalitis]] and he and his colleagues were successful in developing a new DNA-based vaccine against rabies.<ref name="BurmaChakravorty2011">{{cite book|author1=D. P. Burma|author2=Maharani Chakravorty|title=From Physiology and Chemistry to Biochemistry|url=https://books.google.com/books?id=4CaQ3-x3LXMC&pg=PA464|year=2011|publisher=Pearson Education India|isbn=978-81-317-3220-5|pages=464–}}</ref> Later, they improved the vaccine performance by combining the DNA-based rabies vaccine with a controlled quantity of inactivated virus prepared through cell culture.<ref name="DNA vaccines can be produced more rapidly than conventional vaccines">{{Cite web |url=http://www.pharmabiz.com/article/detnews.asp?articleid=42376&sectionid=42 |title=DNA vaccines can be produced more rapidly than conventional vaccines |date=3 January 2008 |publisher=Pharmabiz |access-date=1 April 2017 |archive-date=2 April 2017 |archive-url=https://web.archive.org/web/20170402083249/http://www.pharmabiz.com/article/detnews.asp?articleid=42376&sectionid=42 |url-status=dead }}</ref> The work earned Rangarajan and his colleagues [[Patent Cooperation Treaty]]<ref name="PCT/IN2001/000018">{{Cite web |url=https://patentscope.wipo.int/search/en/detail.jsf?docId=WO2002078732 |title=PCT/IN2001/000018 |date=2017 |publisher=World Intellectual Property Organization}}</ref> and Indian patents<ref name="A novel vaccine formulation consisting of dna vaccine inactivated virus">{{Cite web |url=https://www.orbit.com/RenderStaticFirstPage?XPN=zU05rYUn/B3dGqGyRhNS9XfDUqlXTJ5uwQdFuycu4uk= |title=A novel vaccine formulation consisting of dna vaccine inactivated virus |date=2017 |publisher=Orbit}}</ref> and the vaccine, reportedly cheaper to produce than conventional cell culture rabies vaccines, is being marketed by [[Indian Immunologicals Limited]], under the brand name, ''Dinarab''.<ref name="IISc-developed rabies vaccine cleared for sale">{{Cite news |url=http://timesofindia.indiatimes.com/city/bengaluru/IISc-developed-rabies-vaccine-cleared-for-sale/articleshow/678230.cms |title=IISc-developed rabies vaccine cleared for sale |date=16 May 2004 |newspaper=The Times of India}}</ref> His studies have been documented by way of a number of articles<ref name="Browse by Fellow">{{Cite web |url=http://repository.ias.ac.in/view/fellows/Rangarajan=3APundi_Narasimhan=3A=3A.html |title=Browse by Fellow |date=2017 |publisher=Indian Academy of Sciences}}</ref>{{Refn|group=note|Please see ''Selected bibliography'' section}} of which many have been listed by online article repositories such as [[Google Scholar]]<ref name="On Google Scholar">{{Cite web |url=https://scholar.google.com/citations?user=uZITxFwAAAAJ&hl=en |title=On Google Scholar |date=2017 |publisher=Google Scholar}}</ref> and [[ResearchGate]].<ref name="On ResearchGate">{{Cite web |url=https://www.researchgate.net/researcher/2113863474_Pundi_N_Rangarajan |title=On ResearchGate |date=2017 }}</ref>

Rangarajan's work has attracted research by other scientists<ref name="Immune Response to DNA Combined Tissue Culture Inactivated anti-rabies Vaccine (DINARAB)">{{Cite web |url=http://indianjournals.com/ijor.aspx?target=ijor:ijcmiid&volume=29&issue=1and2&article=013 |title=Immune Response to DNA Combined Tissue Culture Inactivated anti-rabies Vaccine (DINARAB) |date=2017 |publisher=Indian Journals}}</ref> and he has delivered invited speeches or keynote addresses including the lecture on ''Gene Regulation in Eukaryotes: Diversity in general Transcription factors'' at IIT Madras<ref name="Gene Regulation in Eukaryotes: Diversity in general Transcription factors">{{Cite web |url=http://textofvideo.nptel.iitm.ac.in/104108056/lec3.pdf |title=Gene Regulation in Eukaryotes: Diversity in general Transcription factors |date=2017 |publisher=IIT Madras |access-date=1 April 2017 |archive-date=2 April 2017 |archive-url=https://web.archive.org/web/20170402082551/http://textofvideo.nptel.iitm.ac.in/104108056/lec3.pdf |url-status=dead }}</ref> and the address on ''Transcriptional interference in the methylotrophic yeast, Pichia pastoris'' at [[Indian Institute of Science Education and Research, Thiruvananthapuram]] in October 2012.<ref name="Transcriptional interference in the methylotrophic yeast, Pichia pastoris">{{Cite web |url=http://www.iisertvm.ac.in/colloquiums/read/44/2.phpx |title=Transcriptional interference in the methylotrophic yeast, Pichia pastoris |date=2012 |publisher=IISER, Thiruvananthapuram |access-date=1 April 2017 |archive-date=2 April 2017 |archive-url=https://web.archive.org/web/20170402083303/http://www.iisertvm.ac.in/colloquiums/read/44/2.phpx |url-status=dead }}</ref> He was the co-convenor of the lecture workshop on ''Recent Advances in Biotechnology of Health and Disease'' (BHD-2011) organized by [[Madurai Kamaraj University]] in 2011<ref name="BHD-2011">{{Cite web |url=http://web-japps.ias.ac.in:8080/SEP/Reports/report_lw/217_40.pdf |title=BHD-2011 |date=2017 |publisher=Indian Academy of Sciences}}</ref> and has been involved in conducting open courses on ''Eukaryotic Gene Expression''.<ref name="Eukaryotic Gene Expression - basics and benefits">{{Cite web |url=http://www.chemistry2011.org/resources/IndianInstituteOfScience/EukaryoticGeneExpressionBasicsAndBenefits/ |title=Eukaryotic Gene Expression - basics and benefits |date=2011 |publisher=Chemistry2011 |access-date=1 April 2017 |archive-date=16 July 2018 |archive-url=https://web.archive.org/web/20180716035713/http://www.chemistry2011.org/resources/IndianInstituteOfScience/EukaryoticGeneExpressionBasicsAndBenefits/ |url-status=dead }}</ref>

Rangarajan is married to Radha and the couple has two children, Karthik and Meghana. The family lives in [[Rajajinagar]] in Bengaluru.<ref name="NASI fellows">{{Cite web |url=http://www.nasi.org.in/fellows.asp?RsFilter=R |title=NASI fellows |date=2017 |publisher=National Academy of Sciences, India |access-date=21 November 2017 |archive-date=15 March 2016 |archive-url=https://web.archive.org/web/20160315130140/http://nasi.org.in/fellows.asp?RsFilter=R |url-status=dead }}</ref>

== Awards and honors ==
Rangarajan received the [[National Bioscience Award for Career Development]] of the [[Department of Biotechnology]] in 2001.<ref name="Awardees of National Bioscience Awards for Career Development">{{Cite web |url=http://dbtindia.nic.in/wp-content/uploads/2014/03/list_of_bioscience_awardees.pdf |title=Awardees of National Bioscience Awards for Career Development |date=2016 |publisher=Department of Biotechnology |access-date=2017-11-06 |archive-date=4 March 2018 |archive-url=https://web.archive.org/web/20180304191331/http://dbtindia.nic.in/wp-content/uploads/2014/03/list_of_bioscience_awardees.pdf |url-status=dead }}</ref> The National Academy of Sciences, India elected him as a fellow in 2002.<ref name="NASI Year Book 2015">{{Cite web |url=http://www.nasi.org.in/Year%20Book%202015.pdf |title=NASI Year Book 2015 |date=2017 |publisher=National Academy of Sciences, India |access-date=1 April 2017 |archive-date=6 August 2015 |archive-url=https://web.archive.org/web/20150806211716/http://www.nasi.org.in/Year%20Book%202015.pdf |url-status=dead }}</ref> The Council of Scientific and Industrial Research awarded him Shanti Swarup Bhatnagar Prize, one of the highest Indian science awards in 2007.<ref name="Medical Sciences">{{Cite web |url=http://www.csir.res.in/external/heads/career/award/BPRIZE/Medical_SCIENCES.htm |title=Medical Sciences |date=2017 |publisher=Council of Scientific and Industrial Research |url-status=dead |archive-url=https://web.archive.org/web/20130224074105/http://www.csir.res.in/External/Heads/career/award/BPRIZE/Medical_SCIENCES.htm |archive-date=2013-02-24 }}</ref> The Indian Academy of Sciences elected him as a fellow the same year<ref name="Fellow profile">{{Cite web |url=http://www.ias.ac.in/describe/fellow/Rangarajan,_Prof._Pundi_Narasimhan |title=Fellow profile |date=2017 |publisher=Indian Academy of Sciences}}</ref> and he became an elected fellow of the Indian National Science Academy in 2017.<ref name="Indian fellow">{{Cite web |url=http://insaindia.res.in/disp.php |title=Indian fellow |date=2017 |publisher=Indian National Science Academy}}</ref>{{Refn|group=note|Long link - please click ''R'' and select ''PN Rangarajan'' to see details}}

== Selected bibliography ==
* {{Cite journal |author1=Saha, Sougata |author2=Ramanathan, Anand |author3=Rangarajan, Pundi N. |title=Regulation of Ca2+/calmodulin kinase II inhibitor α (CaMKIINα) in virus-infected mouse brain |journal=Biochemical and Biophysical Research Communications |date=2006 |volume=350 |issue=2 |pages=444–449 |doi=10.1016/j.bbrc.2006.09.066|pmid=17010311 }}
* {{Cite journal |author1=Nagendrakumar, S. B. |author2=Madhanmohan, M. |author3=Rangarajan, P. N. |author4=Srinivasan, V. A. |title=Genetic analysis of foot-and-mouth disease virus serotype A of Indian origin and detection of positive selection and recombination in leader protease- and capsid-coding regions |journal=Journal of Biosciences |date=2009 |volume=34 |issue=1 |pages=85–101 |doi=10.1007/s12038-009-0011-9|pmid=19430121 |pmc=7090849 }}
* {{Cite journal |author1=Nagaraj, Viswanathan Arun |author2=Prasad, Dasari |author3=Rangarajan, Pundi N. |author4=Padmanaban, Govindarajan |title=Mitochondrial localization of functional ferrochelatase from Plasmodium falciparum |journal=Molecular and Biochemical Parasitology |date=2009 |volume=168 |issue=1 |pages=109–112 |doi=10.1016/j.molbiopara.2009.05.008|pmid=19523497 }}
* {{Cite journal |author1=Nagaraj, Viswanathan Arun |author2=Prasad, Dasari |author3=Arumugam, Rajavel |author4=Rangarajan, Pundi N. |author5=Padmanaban, Govindarajan |title=Characterization of coproporphyrinogen III oxidase in Plasmodium falciparum cytosol |journal=Parasitology International |date=2010 |volume=59 |issue=2 |pages=121–127 |doi=10.1016/j.parint.2009.12.001|pmid=20006984 }}
* {{Cite journal |author1=Vijay Kumar, N. |author2=Rangarajan, P. N. |title=Catabolite repression of phosphoenolpyruvate carboxykinase by a zinc finger protein under biotin- and pyruvate carboxylase-deficient conditions in Pichia pastoris |journal=Microbiology |date=2011 |volume=157 |issue=12 |pages=3361–3369 |doi=10.1099/mic.0.053488-0|pmid=21948049 |doi-access=free }}

== See also ==
{{Div col|colwidth=30em}}
* [[Rabies vaccine]]
* [[Foot-and-mouth disease]]
* [[Plasmodium falciparum]]
* [[Catabolite repression]]
{{div col end}}
{{portal|India|Medicine}}

== Notes ==
{{reflist|group=note|2}}

== References ==
{{reflist}}

== External links ==
* {{Cite news |url=http://www.hindustantimes.com/delhi/shanti-swarup-bhatnagar-prize-for-2007-given-away/story-cZ7AjiGfbPBD6YaqCFC8eI.html |title=Shanti Swarup Bhatnagar Prize for 2007 given away |date=20 December 2008 |newspaper=Hindustan Times }}
* {{Cite web |url=http://loop.frontiersin.org/people/255718/overview |title=Pundi Narasimhan Rangarajan |date=2017 |publisher=Loop |work=List of articles}}

{{SSBPST recipients in Medical Science}}
{{Shanti Swarup Bhatnagar Laureates of Karnataka}}

{{authority control}}

{{DEFAULTSORT:Rangarajan, P. N.}}
[[Category:1963 births]]
[[Category:Indian medical writers]]
[[Category:20th-century Indian inventors]]
[[Category:Scientists from Bengaluru]]
[[Category:Indian virologists]]
[[Category:Indian biochemists]]
[[Category:Indian Institute of Science alumni]]
[[Category:Academic staff of the Indian Institute of Science]]
[[Category:Fellows of the Indian Academy of Sciences]]
[[Category:Fellows of the Indian National Science Academy]]
[[Category:Fellows of the National Academy of Sciences, India]]
[[Category:Recipients of the Shanti Swarup Bhatnagar Award in Medical Science]]
[[Category:Living people]]
[[Category:21st-century Indian inventors]]

P. N. Rangarajan - Revision history

ChristinaQ73: put up a stub - done