https://en.bharatpedia.org/w/index.php?action=history&feed=atom&title=Nirmal_Kumar_DuttaNirmal Kumar Dutta - Revision history2026-09-07T11:20:13ZRevision history for this page on the wikiMediaWiki 1.43.6https://en.bharatpedia.org/w/index.php?title=Nirmal_Kumar_Dutta&diff=116181&oldid=prev>Citation bot: Alter: url. URLs might have been anonymized. | Use this bot. Report bugs. | Suggested by Abductive | Category:University of Calcutta alumni | via #UCB_Category 1404/14212021-03-20T04:37:22Z<p>Alter: url. URLs might have been anonymized. | <a href="https://en.bharatpedia.org/wiki/BP:UCB" class="extiw" title="wp:UCB">Use this bot</a>. <a href="https://en.bharatpedia.org/wiki/BP:DBUG" class="extiw" title="wp:DBUG">Report bugs</a>. | Suggested by Abductive | <a href="/wiki/Category:University_of_Calcutta_alumni" title="Category:University of Calcutta alumni">Category:University of Calcutta alumni</a> | via #UCB_Category 1404/1421</p>
<p><b>New page</b></p><div>{{Use dmy dates|date=August 2018}}<br />
{{Use Indian English|date=August 2018}}<br />
{{Infobox scientist<br />
| name = Nirmal Kumar Dutta<br />
| image = Dr. Nirmal Kumar Dutta.jpg<br />
| alt = <br />
| caption = Dr. Nirmal Kumar Dutta<br />
| birth_date = {{Birth date|df=yes|1913|12|1}}<br />
| birth_place = [[West Bengal]], India<br />
| death_date = {{Death date and age|df=yes|1982|5|2|1913|12|1}}<br />
| death_place = <br />
| residence = <br />
| nationality = [[Indian nationality|Indian]]<br />
| fields = {{ublist | [[Pharmacology]] }}<br />
| workplaces = {{ublist | [[Haffkine Institute]] | [[Indian Council of Medical Research]] }}<br />
| alma_mater = {{ublist | [[University of Calcutta]] | [[Oxford University]] }}<br />
| doctoral_advisor = <br />
| doctoral_students = <br />
| known_for = Pharmacological studies on [[cholera]]<br />
| awards = {{ublist|1955&nbsp;[[Indian Council of Medical Research|ICMR]] Basantidevi Amirchand Award | 1965&nbsp;Watumull Foundation Award | 1965&nbsp;[[Shanti Swarup Bhatnagar Prize]] | 1981&nbsp;[[Indian National Science Academy|INSA]] Shree Dhanwantar Prize }}<br />
}}<br />
'''Nirmal Kumar Dutta''' (1913–1982) was an Indian pharmacologist, medical academic and the director of [[Haffkine Institute]], Mumbai. He was known for his contributions to the studies on [[cholera]]<ref name="Brief Profile of the Awardee">{{Cite web |url=http://ssbprize.gov.in/content/Detail.aspx?AID=302 |title=Brief Profile of the Awardee |date=2017 |publisher=Shanti Swarup Bhatnagar Prize}}</ref> and was an elected fellow of the [[National Academy of Medical Sciences]],<ref name="NAMS Deceased Fellows">{{Cite web |url=http://nams-india.in/downloads/obit.pdf |title=NAMS Deceased Fellows |date=2017 |publisher=National Academy of Medical Sciences}}</ref> [[National Academy of Sciences, India]] and the [[Indian National Science Academy]].<ref name="Deceased fellow - NK Dutta">{{Cite web |url=http://insaindia.res.in/detail/N63-0231 |title=Deceased fellow - NK Dutta |date=2017-11-16 |publisher=Indian National Science Academy |access-date=2017-11-16}}</ref> The [[Council of Scientific and Industrial Research]], the apex agency of the Government of India for scientific research, awarded him the [[Shanti Swarup Bhatnagar Prize for Science and Technology]], one of the highest Indian science awards for his contributions to Medical Sciences in 1965.<ref name="View Bhatnagar Awardees">{{cite web | url=http://ssbprize.gov.in/Content/AwardeeList.aspx | title=View Bhatnagar Awardees | publisher=Shanti Swarup Bhatnagar Prize | date=2016 | access-date=12 November 2016}}</ref>{{Refn|group=note|Long link - please select award year to see details}}<br />
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== Biography ==<br />
[[File:Calcuttamedicalcollege1.jpg|thumb|left|235px|Calcutta Medical College in 1910]]<br />
N. K. Dutta, born on 1 December 1913 in the Indian state of [[West Bengal]], did his graduate studies in medicine at [[Calcutta Medical College]] of the [[University of Calcutta]] and after earning an MBBS, moved to [[Oxford University]] for his higher studies from where he secured a DPhil in 1949.<ref name="Deceased fellow - NK Dutta" /> Subsequently, he had a second stint at Oxford when he received the degree of DSc from the institution in 1964. A major part of his career was at [[Haffkine Institute]], one of the oldest medical research institutes in India where he served as its director. He also served as the deputy director general of the [[Indian Council of Medical Research]].<br />
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Dutta did extensive researches on [[cholera]] and pioneered the use of infant rabbits for developing a laboratory model for the studies which is reported to have promoted cholera studies in countries where the disease was not prevalent.<ref name="Brief Profile of the Awardee" /> In 1959, he identified the toxin generated by [[Vibrio cholerae]] which causes [[diarrhoea]] during [[animal testing]]<ref name="Barua1992">{{cite book|author=Dhiman Barua|title=Cholera|url=https://books.google.com/books?id=HRwGkfyNv6AC&pg=PA158|date=30 September 1992|publisher=Springer Science & Business Media|isbn=978-0-306-44077-9|pages=158–}}</ref> and he used the classical biotype, Inaba serotype, ''V. cholerae'' strain 569B for the first time,<ref>{{Cite book|url=https://books.google.com/books?id=7z99Jkrd3jYC&q=who+first+used+569B+strain&pg=PA10|title=Handbook of Natural Toxins: Bacterial Toxins|last1=Hardegree|first1=M. Carolyn|last2=Tu|first2=Anthony T.|date=1988-08-05|publisher=CRC Press|isbn=978-0-8247-7840-8|language=en}}</ref> which is being followed today.<ref name="BurmaChakravorty2011">{{cite book|author1=D. P. Burma|author2=Maharani Chakravorty|title=From Physiology and Chemistry to Biochemistry |url=https://books.google.com/books?id=4CaQ3-x3LXMC&pg=PA252|year=2011|publisher=Pearson Education India|isbn=978-81-317-3220-5|pages=252–}}</ref> He also developed a methodology for the evaluation of vaccines and [[antiserum]] and was known to have proposed therapeutic protocols for treating cholera.<ref name="A new approach to the treatment of cholera based on experimental evidence">{{Cite journal |last=N. K. Dutta, N. B. Oza |title=A new approach to the treatment of cholera based on experimental evidence |journal=Br J Exp Pathol. |publication-date=1965 |volume=46 |issue=4 |pages=418–421 |pmc=2094611 |pmid=5825777|year=1965 }}</ref> He documented his researches by way of several medical papers published in peer-reviewed journals<ref name="Author profile">{{Cite journal|title=Author profile |journal = Journal of Bacteriology|volume = 78|pages = 594–5|date=2017 |pmid=13818912 |pmc = 290591|author1 = DUTTA NK|author2 = PANSE MV|author3 = KULKARNI DR|doi = 10.1128/JB.78.4.594-595.1959}}</ref>{{Refn|group=note|Please see ''Selected bibliography'' section}} and his work has been cited by a number of authors and researchers.<ref name="Motohashi2008">{{cite book|author=Noboru Motohashi|title=Bioactive Heterocycles VI: Flavonoids and Anthocyanins in Plants, and Latest Bioactive Heterocycles I|url=https://books.google.com/books?id=1j1uCQAAQBAJ&pg=PA79|date=2 July 2008|publisher=Springer|isbn=978-3-540-79218-5|pages=79–}}</ref><ref name="JUCKER2013">{{cite book|author=JUCKER|title=Progress in Drug Research / Fortschritte der Arzneimittelforschung / Progrès des recherches pharmaceutiques: Tropical Diseases II / Tropische Krankheiten II / Maladies tropicales II|url=https://books.google.com/books?id=0sHzBwAAQBAJ&pg=PA641|date=13 March 2013|publisher=Birkhäuser|isbn=978-3-0348-7090-0|pages=641–}}</ref><ref name="Experimental cholera in humans">{{cite journal |pmc=1843319 |title=Experimental cholera in humans |journal=British Medical Journal |volume=1 |issue=5480 |pages=140–142 |date=2017|last1=Benyajati |first1=C |pmid=5901572 |doi=10.1136/bmj.1.5480.140 }}</ref><ref name="Cholera Toxins: Immunogenicity of the Rabbit Ileal Loop Toxin and Related Antigens">{{Cite web |url=http://jb.asm.org/content/100/2/985.full.pdf |title=Cholera Toxins: Immunogenicity of the Rabbit Ileal Loop Toxin and Related Antigens |date=2017 |publisher=American Society for Microbiology}}</ref><br />
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Dutta was associated with the [[World Health Organization]], serving as a member of their Experts' Panel in Bacterial Diseases and Cholera.<ref name="Deceased fellow - NK Dutta" /> He was a member of the [[Indian Pharmacopoeia Commission]] and the Drugs Technical Advisory Board of the Government of India and sat in the Expert Scientific Committee of Indian Council of Medical Research. He was also a member of the editorial boards of Archives internationales de Pharmacodynamie et de Thérapie and the [[Indian Journal of Pharmacology]] and served as the president of the Maharashtra chapter of the Indian Pharmaceutical Association. He died on 2 May 1982, at the age of 68.<ref name="Brief Profile of the Awardee" /><br />
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== Awards and honors ==<br />
Dutta received the Basantidevi Amirchand Award of the [[Indian Council of Medical Research]] in 1955 and the Watumull Foundation Award in Medicine in 1965;<ref name="Deceased fellow - NK Dutta" /> the same year as the [[Council of Scientific and Industrial Research]] awarded him [[Shanti Swarup Bhatnagar Prize]], one of the highest Indian science awards.<ref name="Medical Sciences">{{Cite web |url=http://www.csir.res.in/external/heads/career/award/BPRIZE/Medical_SCIENCES.htm |title=Medical Sciences |date=2017 |publisher=Council of Scientific and Industrial Research |url-status=dead |archive-url=https://web.archive.org/web/20130224074105/http://www.csir.res.in/External/Heads/career/award/BPRIZE/Medical_SCIENCES.htm |archive-date=2013-02-24 }}</ref> In between, the [[Indian National Science Academy]] elected him as a fellow in 1963; INSA would honor him again with the Shree Dhanwantari Prize in 1981.<ref name="Shree Dhanwantari Prize">{{Cite web |url=http://insaindia.res.in/recipients.php#sdp |title=Shree Dhanwantari Prize |date=2017 |publisher=Indian National Science Academy}}</ref> He was also a fellow of the [[National Academy of Sciences, India]] and the [[National Academy of Medical Sciences]].<ref name="NAMS Deceased Fellows" /><br />
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== Selected bibliography ==<br />
* {{Cite journal |last=Dutta N. K., Habbu M. K. |title=Experimental cholera in infant rabbits: a method for chemotherapeutic investigation |journal=Br J Pharmacol Chemother |publication-date=1955 |volume=10 |issue=2 |pages=153–9 |pmid=14389652 |pmc=1509487 |doi=10.1111/j.1476-5381.1955.tb00074.x|year=1955 }}<br />
* {{Cite journal |last=Dutta N. K., Panse N. V., Kulkarni D. R. |title=Role of cholera a toxin in experimental cholera |journal=J. Bacteriol. |publication-date=1959 |volume=78 |pages=594–5 |pmid=13818912 |pmc=290591|year=1959 |issue=4 |doi=10.1128/JB.78.4.594-595.1959 }}<br />
* {{Cite journal |last=Dutta N. K., Panse N. V. |title=An experimental study on the usefulness of bacteriophage in the prophylaxis and treatment of cholera |journal=Bull World Health Organ |publication-date=1963 |volume=28 |issue=3 |pages=357–60 |pmid=20604146 |pmc=2554721|year=1963 }}<br />
* {{Cite journal |last=Dutta N. K., Panse N. V., Jhala H. I. |title=Choleragenic Property of Certain Strains of El Tor, Non-agglutinable, and Water Vibrios Confirmed Experimentally |journal=Br Med J |publication-date=1963 |volume=1 |issue=5339 |pages=1200–3 |pmid=20789782 |pmc=2123573|year=1963 |doi=10.1136/bmj.1.5339.1200 }}<br />
* {{Cite journal |last=Williams E. M., Dohadwalla A. N., Dutta N. K. |title=Diarrhea and accumulation of intestinal fluid in infant rabbits infected with Vibrio cholerae in an isolated jejunal segment |journal=J Infect Dis |publication-date=1969 |volume=120 |issue=6 |pages=645–51 |pmid=5374968|year=1969 |doi=10.1093/infdis/120.6.645}}<br />
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== See also ==<br />
{{Div col|colwidth=30em}}<br />
* [[Robert Koch]]<br />
* [[Timeline of cholera]]<br />
{{div col end}}<br />
{{portal|India|Medicine}}<br />
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== Notes ==<br />
{{reflist|group=note}}<br />
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== References ==<br />
{{reflist}}<br />
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== External links ==<br />
* {{Cite journal |last=N. K. Dutta, N. B. Oza |title=A new approach to the treatment of cholera based on experimental evidence |journal=Br J Exp Pathol. |publication-date=1965 |volume=46 |issue=4 |pages=418–421 |pmc=2094611 |pmid=5825777|year=1965 }}<br />
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{{SSBPST recipients in Medical Science}}<br />
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{{DEFAULTSORT:Dutta, Nirmal Kumar}}<br />
[[Category:Recipients of the Shanti Swarup Bhatnagar Award in Medical Science]]<br />
[[Category:1913 births]]<br />
[[Category:Indian medical writers]]<br />
[[Category:20th-century Indian medical doctors]]<br />
[[Category:Fellows of the National Academy of Medical Sciences]]<br />
[[Category:1982 deaths]]<br />
[[Category:Medical doctors from West Bengal]]<br />
[[Category:University of Calcutta alumni]]<br />
[[Category:Alumni of the University of Oxford]]<br />
[[Category:Indian Council of Medical Research]]<br />
[[Category:World Health Organization officials]]<br />
[[Category:Fellows of the Indian National Science Academy]]<br />
[[Category:Fellows of The National Academy of Sciences, India]]<br />
[[Category:Indian officials of the United Nations]]</div>>Citation bot