>Ssilvers: Reverted edits by PiratePuppy (talk) to last version by The Eloquent Peasant

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Reverted edits by PiratePuppy (talk) to last version by The Eloquent Peasant

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{{short description|Indian structural biologist}}
{{Use dmy dates|date=January 2019}}
{{Use Indian English|date=January 2019}}
{{Infobox scientist
| name = Nagasuma Chandra
| image =
| alt =
| caption =
| birth_date =
| birth_place = [[Karnataka]], India
| death_date =
| death_place =
| residence = [[Bengaluru]], Karnataka, India
| nationality = [[Indian nationality|Indian]]
| fields = {{ublist | [[Structural biology]] | [[biochemistry]] }}
| workplaces = {{ublist | [[Cipla]] | [[Indian Institute of Science]] }}
| alma_mater = {{ublist | [[Bangalore University]] | [[University of Bristol]] | [[Indian Institute of Science]] }}
| doctoral_advisor =
| doctoral_students =
| known_for = Studies on [[Mycobacterium tuberculosis]]
| awards = {{ublist| 2008 [[National Bioscience Award for Career Development|N-BIOS Prize]] }}
}}
'''Nagasuma Chandra''' is an Indian structural biologist, biochemist and a professor at the department of biochemistry of the [[Indian Institute of Science]]. She is known for her studies on [[Mycobacterium tuberculosis]]. The [[Department of Biotechnology]] of the Government of India awarded her the [[National Bioscience Award for Career Development]], one of the highest Indian science awards, for her contributions to biosciences in 2008.

== Biography ==
[[File:Bangaloreuniversity.jpg|thumb|left|[[Bangalore University]].]]
Nagasuma Chandra, born in the south Indian state of [[Karnataka]], completed her undergraduate (BPharm) and post-graduate (MPharm) studies at the [[Bangalore University]] and moved to the UK from where she secured a PhD from the [[University of Bristol]] in 1992.<ref name="Drug Discovery India 2017 Speaker Biography">{{Cite web |url=https://selectbiosciences.com/conferences/biographies.aspx?speaker=346018&conf=ddi2017&se=india |title=Drug Discovery India 2017 Speaker Biography |date=2018-01-17 |website=SELECTBIO |access-date=2018-01-17}}</ref> She did her post-doctoral work at the Molecular Biophysics Unit (MBU) of the [[Indian Institute of Sciences]] (IISc) from 1992 to 1997 and joined IISc as a research scientist the same year.<ref name="Faculty profile">{{Cite web |url=http://www.biochem.iisc.ernet.in/nchandra.php |title=Faculty profile |website=www.biochem.iisc.ernet.in |language=en |access-date=2018-01-17}}</ref> A year later, she became a faculty of bioinformatics of the institute<ref name="Systems biology">{{Cite journal |last1=Raman |first1=Karthik |last2=Chandra |first2=Nagasuma |date=2010-02-01 |title=Systems biology |journal=Resonance |language=en |volume=15 |issue=2 |pages=131–153 |doi=10.1007/s12045-010-0015-7 |s2cid=195299490 |issn=0971-8044|url=https://www.zora.uzh.ch/id/eprint/156224/1/ZORA_NL_156224.pdf }}</ref> where she holds the position of a professor. At IISc, she has set up a systems biology and computational biochemistry laboratory, popularly known as Chandralab,<ref name="Chandra Lab - Department of Biochemistry">{{Cite web |url=http://proline.physics.iisc.ernet.in/chandralab/ |title=Chandra Lab - Department of Biochemistry |website=proline.physics.iisc.ernet.in |language=en |access-date=2018-01-17}}</ref> and hosts several research scholars.<ref name="Chandra Lab - Team">{{Cite web |url=http://proline.physics.iisc.ernet.in/chandralab/team.php |title=Chandra Lab - Team |date=2018-01-17 |website=proline.physics.iisc.ernet.in |language=en |access-date=2018-01-17}}</ref> She also serves as a faculty at the ''National Network for Mathematical and Computational Biology'', an educational agency funded by the [[Science and Engineering Research Board]] of the Government of India.<ref name="Nagasuma Chandra - National Network for Mathematical and Computational Biology">{{Cite web |url=http://www.iiserpune.ac.in/~mbio/?q=nnmcb/people/nagasuma-chandra |title=Nagasuma Chandra - National Network for Mathematical and Computational Biology |website=www.iiserpune.ac.in |language=en |access-date=2018-01-17}}</ref>

== Legacy ==
[[File:201708 Mycobacterium tuberculosis.svg|thumb|Mycobacterium tuberculosis]]
Chandra's research focus is in the fields of computational systems biology, cell modeling and structural bioinformatics<ref name="Systems biology" /> and she leads a team of scientists who are involved in research in areas such as systems biology, computational immunology, structural bioinformatics and drug discovery.<ref name="Chandra Lab - Department of Biochemistry" /> She has carried out studies on [[Mycobacterium tuberculosis]], the causative pathogen of [[tuberculosis]], with special emphasis on their metabolic processes and, along with [[M. Vijayan]] and [[K. Sekar]], two of her colleagues at IISc,<ref name="BurmaChakravorty2011">{{cite book|author1=D. P. Burma|author2=Maharani Chakravorty|title=From Physiology and Chemistry to Biochemistry|url=https://books.google.com/books?id=4CaQ3-x3LXMC&pg=PA389|year=2011|publisher=Pearson Education India|isbn=978-81-317-3220-5|pages=389–}}</ref> has developed [[Systems modeling|system models]] which has helped identify new drug targets against the disease.<ref name="Nagasuma Chandra - Division of Biological Sciences, Indian Institute of Science">{{Cite web |url=http://bio.iisc.ac.in/?q=faculty/nagasuma-chandra |title=Nagasuma Chandra - Division of Biological Sciences, Indian Institute of Science |date=2018-01-17 |website=bio.iisc.ac.in |access-date=2018-01-17}}</ref> In 2017, the team led by her identified three drugs namely [[Ebselen]], [[Vancomycin]] and [[Phenylarsine oxide]] that could be used in combination with [[Isoniazid]], the principal antibiotic used against tuberculosis, to treat the drug-resistant strains of the pathogen.<ref name="Scientists find ways to reverse drug resistance, a major burden in treating Tuberculosis">{{Cite news |url=https://researchmatters.in/article/scientists-find-ways-reverse-drug-resistance-major-burden-treating-tuberculosis |title=Scientists find ways to reverse drug resistance, a major burden in treating Tuberculosis |date=2017-02-08 |work=Research Matters |access-date=2018-01-17 |language=en}}</ref> The team discovered that the three drugs lowered the antioxidant levels in the bacterium and thereby destroyed its drug-resistance.<ref name="City scientists deliver killer punch to drug-resistant TB">{{Cite news |url=http://bangaloremirror.indiatimes.com/bangalore/others/city-scientists-deliver-killer-punch-to-drug-resistant-tb/articleshow/57997366.cms |title=City scientists deliver killer punch to drug-resistant TB |work=Bangalore Mirror |access-date=2018-01-17}}</ref> Her studies have been documented by way of a number of articles<ref name="On Google Scholar">{{Cite web |url=https://scholar.google.co.in/citations?user=BG3m00QAAAAJ |title=On Google Scholar |date=2018-01-08 |publisher=Google Scholar |access-date=2018-01-08}}</ref>{{Refn|group=note|Please see ''Selected bibliography'' section}} and [[ResearchGate]], an online repository of scientific articles has listed 297 of them.<ref name="On ResearchGate">{{Cite web |url=https://www.researchgate.net/profile/Nagasuma_Chandra2 |title=On ResearchGate |date=2018-01-09 |access-date=2018-01-09}}</ref> She has also delivered invited speeches at various seminars and conferences.<ref name="Drug Discovery India 2017 Speaker Biography" /><ref name="Systems biology and protein interaction network">{{Cite web |url=http://www.rcb.res.in/upload/2013/Workshop2013_12.pdf |title=Systems biology and protein interaction network |date=2018-01-17 |website=Regional Centre for Biotechnology |access-date=2018-01-17}}</ref>

== Awards and honors ==
The [[Department of Biotechnology]] of the Government of India awarded her the [[National Bioscience Award for Career Development]], one of the highest Indian science awards in 2008.<ref name="Awardees of National Bioscience Awards for Career Development">{{Cite web |url=http://dbtindia.nic.in/wp-content/uploads/2014/03/list_of_bioscience_awardees.pdf |title=Awardees of National Bioscience Awards for Career Development |date=2016 |publisher=Department of Biotechnology |access-date=2017-11-20}}</ref>

== Selected bibliography ==
* {{cite journal | last1=Bhagavat | first1=Raghu | last2=Sankar | first2=Santhosh | last3=Srinivasan | first3=Narayanaswamy | last4=Chandra | first4=Nagasuma | title=An Augmented Pocketome: Detection and Analysis of Small-Molecule Binding Pockets in Proteins of Known 3D Structure | journal=Structure | publisher=Elsevier BV | volume=26 | issue=3 | year=2018 | issn=0969-2126 | doi=10.1016/j.str.2018.02.001 | pages=499–512.e2 |display-authors=1|pmid=29514079|url=http://www.cell.com/structure/fulltext/S0969-2126(18)30041-8| doi-access=free }}
* {{Cite journal |last1=Anand |first1=Praveen |last2=Chandra |first2=Nagasuma |date=2014-09-15 |title=Characterizing the pocketome of Mycobacterium tuberculosis and application in rationalizing polypharmacological target selection |journal=Scientific Reports |language=En |volume=4 |issue=1 |pages=6356 |doi=10.1038/srep06356 |pmid=25220818 |pmc=5376175 |issn=2045-2322}}
* {{Cite journal |last1=Chandra |first1=Nagasuma |last2=Padiadpu |first2=Jyothi |title=Network approaches to drug discovery |journal=Expert Opinion on Drug Discovery |volume=8 |issue=1 |pages=7–20 |doi=10.1517/17460441.2013.741119|pmid=23140510 |year=2013 |s2cid=21595087 }}
* {{Cite journal |last1=Bhagavat |first1=Raghu |last2=Chandra |first2=Nagasuma |date=2014-01-01 |title=Common recognition principles across diverse sequence and structural families of sialic acid binding proteins |url=https://academic.oup.com/glycob/article/24/1/5/1988383 |journal=Glycobiology |volume=24 |issue=1 |pages=5–16 |doi=10.1093/glycob/cwt063 |pmid=24043392 |issn=0959-6658|doi-access=free }}

== See also ==
{{Div col|colwidth=30em}}
* [[Genome analysis]]
* [[Human iron metabolism]]
{{Div col end}}
{{portal|India|Biology|Medicine}}

== Notes ==
{{reflist|group=note|2}}

== References ==
{{reflist}}

== External links ==
* {{Cite web |url=https://www.youtube.com/watch?v=rKITRrlY-Xc |title=Can biology be a predictive science ? |last=Nagasuma Chandra |date=4 May 2017 |publisher= IISc Naturalists |format=YouTube video |access-date=2018-01-17}}

{{N-BIOS Laureates 1999–2009}}
{{authority control}}

{{DEFAULTSORT:Chandra, Nagasuma}}
[[Category:N-BIOS Prize recipients]]
[[Category:Indian scientific authors]]
[[Category:Living people]]
[[Category:Indian Institute of Science alumni]]
[[Category:Indian molecular biologists]]
[[Category:Scientists from Bangalore]]
[[Category:Indian bioinformaticians]]
[[Category:Indian biochemists]]
[[Category:Bangalore University alumni]]
[[Category:University of Bristol]]
[[Category:Indian Institute of Science faculty]]
[[Category:Year of birth missing (living people)]]

Nagasuma Chandra - Revision history

>Ssilvers: Reverted edits by PiratePuppy (talk) to last version by The Eloquent Peasant