https://en.bharatpedia.org/w/index.php?action=history&feed=atom&title=Madhusoodan_V._HosurMadhusoodan V. Hosur - Revision history2026-11-06T00:54:24ZRevision history for this page on the wikiMediaWiki 1.43.6https://en.bharatpedia.org/w/index.php?title=Madhusoodan_V._Hosur&diff=514497&oldid=prevNiishad Shetty: put up data...2026-01-08T19:58:10Z<p>put up data...</p>
<p><b>New page</b></p><div>{{Short description|Indian structural biologist}}<br />
{{Use Indian English|date=November 2025}}<br />
{{Use dmy dates|date=November 2025}}<br />
{{For|Indian biophysical scientist|Ramakrishna V. Hosur}}<br />
{{Infobox scientist<br />
| name = Madhusoodan V. Hosur<br />
| image = Prof MV Hosur.png<br />
| alt = <br />
| birth_date = {{birth date and age|df=y|1950|12|24}}<ref name="main"/><br />
| birth_place = India<br />
| fields = {{plainlist|<br />
* [[Structural biology]]<br />
* [[Crystallography]]<br />
}}<br />
| workplaces = {{plainlist|<br />
* [[Bhabha Atomic Research Centre]]<br />
* [[ACTREC]] ''of'' [[Tata Memorial Centre]]<br />
* [[National Institute of Advanced Studies]]<br />
}}<br />
| alma_mater = {{plainlist| <br />
* [[Indian Institute of Science]]<br />
* [[Karnatak University]]<br />
}}<br />
| awards = {{plainlist|<br />
* [[Fellow]] of the [[Indian National Science Academy]] (2010)<br />
}}<br />
| known_for = Structural studies of [[HIV-1 protease]]; Viral [[protein crystallography]]; [[Drug design]] research<br />
}}<br />
'''Madhusoodan Vijayacharya Hosur''' (born 24 December 1950) also known as '''MV Hosur''' is an Indian structural biologist and crystallographer known for his work on macromolecular crystallography, including viral and HIV-1 protease structures, and for contributions to drug-design research.<br />
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==Early life and education==<br />
He received his Ph.D. in [[X-ray crystallography]] of [[nucleotides]], [[coenzymes]] and high-energy [[phosphates]] from the [[Indian Institute of Science]] (IISc), [[Bengaluru]], India during (1973–1979).<ref>{{cite book |last1=Kannan |first1=K. K. |chapter=India |title=World Directory of Crystallographers |date=1995 |pages=80–87 |doi=10.1007/978-94-017-3699-2_29 |isbn=978-0-7923-3180-3 }}</ref><ref>{{cite journal |last1=Viswamitra |first1=M. A. |last2=Hosur |first2=M. V. |last3=Shakked |first3=Zippora |last4=Kennard |first4=Olga |title=X-ray study of the rubidium salt of ADP |journal=Nature |date=July 1976 |volume=262 |issue=5565 |pages=234–236 |doi=10.1038/262234a0 |pmid=934342 |bibcode=1976Natur.262..234V }}</ref><br />
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He then carried out early work as a Research Associate, [[University of Wisconsin–Madison]] (1979–1981), on the X-ray crystallography of [[oligonucleotides]]. Later he worked at the [[Purdue University]] (1982–1986) on the X-ray structure of spherical viruses.<ref>{{cite journal |last1=Zhang |first1=X |last2=Sun |first2=S |last3=Xiang |first3=Y |last4=Wong |first4=J |last5=Klose |first5=T |last6=Raoult |first6=D |last7=Rossmann |first7=MG |title=Structure of Sputnik, a virophage, at 3.5-Å resolution. |journal=Proceedings of the National Academy of Sciences of the United States of America |date=6 November 2012 |volume=109 |issue=45 |pages=18431–6 |doi=10.1073/pnas.1211702109 |doi-access=free |pmid=23091035 |pmc=3494952 |bibcode=2012PNAS..10918431Z }}</ref><ref name="main">{{cite web |title=Madhusoodan Hosur |url=https://cms.nias.res.in/people/people/madhusoodan-hosur |website=cms.nias.res.in |publisher=[[National Institute of Advanced Studies]] |access-date=15 November 2025}}</ref><br />
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==Career==<br />
He joined [[Bhabha Atomic Research Centre|BARC]], Mumbai, as Scientific Officer in 1986 and stayed there until 1999 on the work related to macromolecular crystallography and drug‐design.<ref>{{cite news |title=Form and Function of Biomolecules Macromolecular crystallography in India {{!}} Historical Profile through Publications (1981–2015) |url=http://mbu.iisc.ac.in/mvlab/public_html/booklet.pdf |access-date=15 November 2025 |work=mbu.iisc.ac.in |publisher=Molecular Biophysics Unit, [[Indian Institute of Science]]}}</ref><br />
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From 1999 to 2012, he was with the Protein Crystallography Section, Solid-State Physics Division (SSPD) at BARC as head. His work was focused on viral [[protein structures]], malaria proteins, and drug-resistance mechanisms. Later he moved to the [[Advanced Centre for Treatment Research and Education in Cancer]] (ACTREC) in Navi Mumbai, continuing his research in biophysics, crystallography, and big-data epilepsy from 2013 to 2016.<ref>{{cite news |last1=Raskar |first1=Tushar |last2=Khavnekar |first2=Sagar |last3=Hosur |first3=Madhusoodan |title=Time-dependent X-ray diffraction studies on urea/hen egg white lysozyme complexes reveal structural changes that indicate onset of denaturation |url=https://www.nature.com/articles/srep32277 |journal=Scientific Reports |date=30 August 2016 |volume=6 |article-number=32277 |language=en |doi=10.1038/srep32277}}</ref><ref>{{cite web |title=MV Hosur {{!}} Profile |url=https://cms.nias.res.in/sites/default/filesefs/2022-01/Madhusoodan%20Hosur.pdf |website=cms.nias.res.in |publisher=[[National Institute of Advanced Studies]] |access-date=15 November 2025}}</ref><br />
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From 2017 onward, he has been an INSA-Senior scientist<ref>{{cite web |title=Sectional Committees-2020 {{!}} Delhi |url=https://insaindia.res.in/pdf/sc-2020.pdf |website=insaindia.res.in |publisher=[[Indian National Science Academy]] |access-date=15 November 2025}}</ref> and holding [[Adjunct professor|adjunct professorship]] at the [[National Institute of Advanced Studies]], Bangalore. He focuses on big-data approaches in epilepsy and other biomedical fields.<ref name="main"/><ref>{{cite book |last1=Kumar |first1=Arvind |last2=Janaki |first2=Chintalapati |last3=Hosur |first3=M. V. |last4=Pal |first4=Supriya N. |chapter=Machine Learning techniques to identify potential drug targets for Anti-epileptic drugs |title=2020 IEEE International Conference on Machine Learning and Applied Network Technologies (ICMLANT) |date=20 December 2020 |pages=1–6 |doi=10.1109/ICMLANT50963.2020.9355971 |isbn=978-1-7281-8885-0 }}</ref><br />
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==Awards and honours==<br />
*[[Fellow]] of the [[Indian National Science Academy]] (INSA) (2010)<ref>{{cite web |title=INSA :: Fellow Detail (P10-1511) |url=https://insajournal.in/intranetinsa/fellow_detail.php?id=P10-1511 |website=insajournal.in |publisher=[[Indian National Science Academy]] |access-date=15 November 2025}}</ref> <br />
*[[Wenner-Gren Foundation for Anthropological Research|Wenner‑Gren]] Visiting Fellowship at [[Lund University]] (2001)<ref>{{cite journal |last1=Kumar |first1=M |last2=Prashar |first2=V |last3=Mahale |first3=S |last4=Hosur |first4=MV |title=Observation of a tetrahedral reaction intermediate in the HIV-1 protease-substrate complex. |journal=The Biochemical Journal |date=15 July 2005 |volume=389 |issue=Pt 2 |pages=365–71 |doi=10.1042/BJ20041804 |pmid=15794743 |pmc=1175113 }}</ref><br />
*[[Martin Onslow Forster|Martin‐Forster]] Gold Medal from [[Indian Institute of Science]] (1979)<ref>{{cite web |title=MV Hosur Bio |url=https://www.ospfound.org/mv-hosur-bio.html |website=OPEN SOURCE PHARMA FOUNDATION |access-date=15 November 2025 |language=en}}</ref><br />
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==Selected Bibliography==<br />
*{{cite journal |last1=Chaudhuri |first1=T |last2=Hosur |first2=MV |title=Molecular modelling reveals how abundance of α4 sub-type in synaptic GABAR(A) receptor can lead to refractoriness toward GABA and BZ-type drugs. |journal=Journal of Biomolecular Structure & Dynamics |date=2024 |volume=42 |issue=24 |pages=13680–13687 |doi=10.1080/07391102.2023.2277858 |pmid=37948195}}<br />
*{{cite journal |last1=Chaudhuri |first1=T |last2=Chintalapati |first2=J |last3=Hosur |first3=MV |title=Identification of 3'-UTR single nucleotide variants and prediction of select protein imbalance in mesial temporal lobe epilepsy patients. |journal=PLOS ONE |date=2021 |volume=16 |issue=6 |article-number=e0252475 |doi=10.1371/journal.pone.0252475 |doi-access=free |pmid=34086756 |pmc=8177469 |bibcode=2021PLoSO..1652475C }}<br />
*{{cite journal |last1=Prashar |first1=V |last2=Bihani |first2=SC |last3=Ferrer |first3=JL |last4=Hosur |first4=MV |title=Structural Basis of Why Nelfinavir-Resistant D30N Mutant of HIV-1 Protease Remains Susceptible to Saquinavir. |journal=Chemical Biology & Drug Design |date=September 2015 |volume=86 |issue=3 |pages=302–8 |doi=10.1111/cbdd.12494 |pmid=25487655}}<br />
*{{cite journal |last1=Bihani |first1=S |last2=Das |first2=A |last3=Prashar |first3=V |last4=Ferrer |first4=JL |last5=Hosur |first5=MV |title=X-ray structure of HIV-1 protease in situ product complex. |journal=Proteins |date=15 February 2009 |volume=74 |issue=3 |pages=594–602 |doi=10.1002/prot.22174 |pmid=18704947}}<br />
*{{cite journal |last1=Prashar |first1=V |last2=Hosur |first2=MV |title=1.8A X-ray structure of C95M/C1095F double mutant of tethered HIV-1 protease dimer complexed with acetyl pepstatin. |journal=Biochemical and Biophysical Research Communications |date=29 October 2004 |volume=323 |issue=4 |pages=1229–35 |doi=10.1016/j.bbrc.2004.08.226 |pmid=15451428 |bibcode=2004BBRC..323.1229P }}<br />
*{{cite journal |last1=Hosur |first1=MV |last2=Sainis |first2=JK |last3=Kannan |first3=KK |title=Crystallization and X-ray analysis of a multienzyme complex containing RUBISCO and RuBP. |journal=Journal of Molecular Biology |date=20 December 1993 |volume=234 |issue=4 |pages=1274–8 |doi=10.1006/jmbi.1993.1681 |pmid=8263930}}<br />
*{{cite journal |last1=Hosur |first1=MV |last2=Schmidt |first2=T |last3=Tucker |first3=RC |last4=Johnson |first4=JE |last5=Gallagher |first5=TM |last6=Selling |first6=BH |last7=Rueckert |first7=RR |title=Structure of an insect virus at 3.0 A resolution. |journal=Proteins |date=1987 |volume=2 |issue=3 |pages=167–76 |doi=10.1002/prot.340020302 |pmid=3447176}}<br />
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==References==<br />
{{reflist}}<br />
{{authority control}}<br />
[[Category:1950 births]]<br />
[[Category:Living people]]<br />
[[Category:Fellows of the Indian National Science Academy]]<br />
[[Category:Indian Institute of Science alumni]]<br />
[[Category:Scientists from Mumbai]]<br />
[[Category:Karnatak University alumni]]<br />
[[Category:Structural biologists]]<br />
[[Category:Indian crystallographers]]</div>Niishad Shetty