Birjesh Kumar: add section per sources and added references as per guidelines

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← Older revision		Revision as of 00:55, 14 August 2023
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	== See also ==		== See also ==
	* [[Sir Derek Barton]]		* [[Sir Derek Barton]]
	~~{{Portal\|India\|Chemistry}}~~

	== Notes ==		== Notes ==

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	* {{Cite journal \|author1=Dewan S. Bhakuni \|author2=Awadhesh N. Singh \|author3=Sudha Jain \|title=Biosynthesis of isotetrandrine \|journal=Tetrahedron \|date=1980 \|volume=36 \|issue=14 \|pages=2149–2151 \|doi=10.1016/0040-4020(80)80107-4}}		* {{Cite journal \|author1=Dewan S. Bhakuni \|author2=Awadhesh N. Singh \|author3=Sudha Jain \|title=Biosynthesis of isotetrandrine \|journal=Tetrahedron \|date=1980 \|volume=36 \|issue=14 \|pages=2149–2151 \|doi=10.1016/0040-4020(80)80107-4}}
	* {{Cite journal \|author1=PP Gupta \|author2=RC Srimal \|author3=K Avasthi \|author4=N Garg \|author5=T Chandra \|author6=DS Bhakuni \|title=Antiallergic activity of alkyl substituted pyrazolo [3, 4-d] pyrimidine (compound 88-765). \|journal=Indian Journal of Experimental Biology \|date=1995 \|volume=33 \|issue=1 \|pages=38–40 \|pmid=9135673}}		* {{Cite journal \|author1=PP Gupta \|author2=RC Srimal \|author3=K Avasthi \|author4=N Garg \|author5=T Chandra \|author6=DS Bhakuni \|title=Antiallergic activity of alkyl substituted pyrazolo [3, 4-d] pyrimidine (compound 88-765). \|journal=Indian Journal of Experimental Biology \|date=1995 \|volume=33 \|issue=1 \|pages=38–40 \|pmid=9135673}}
	* {{Cite journal \|vauthors=Biswas S, Sharma S, Saroha A, Bhakuni DS, Malhotra R, Zahur M, Oellerich M, Das HR, Asif AR \|title=Identification of novel autoantigen in the synovial fluid of rheumatoid arthritis patients using an immunoproteomics approach \|journal=PLOS ONE \|date=2013 \|volume=8 \|issue=2 \|pages=e56246 \|doi=10.1371/journal.pone.0056246\|pmid=23418544 \|bibcode=2013PLoSO...856246B\|pmc=3572018}}		* {{Cite journal \|vauthors=Biswas S, Sharma S, Saroha A, Bhakuni DS, Malhotra R, Zahur M, Oellerich M, Das HR, Asif AR \|title=Identification of novel autoantigen in the synovial fluid of rheumatoid arthritis patients using an immunoproteomics approach \|journal=PLOS ONE \|date=2013 \|volume=8 \|issue=2 \|pages=e56246 \|doi=10.1371/journal.pone.0056246\|pmid=23418544 \|bibcode=2013PLoSO...856246B\|pmc=3572018\|doi-access=free }}
	* {{Cite journal \|vauthors=Sharma S, Ghosh S, Singh LK, Sarkar A, Malhotra R, Garg OP, Singh Y, Sharma RS, Bhakuni DS, Das TK, Biswas S \|title=Identification of autoantibodies against transthyretin for the screening and diagnosis of rheumatoid arthritis \|journal=PLOS ONE \|date=2014 \|volume=9 \|issue=4 \|pages=e93905 \|doi=10.1371/journal.pone.0093905\|pmid=24714506 \|bibcode=2014PLoSO...993905S \|pmc=3979706 }}		* {{Cite journal \|vauthors=Sharma S, Ghosh S, Singh LK, Sarkar A, Malhotra R, Garg OP, Singh Y, Sharma RS, Bhakuni DS, Das TK, Biswas S \|title=Identification of autoantibodies against transthyretin for the screening and diagnosis of rheumatoid arthritis \|journal=PLOS ONE \|date=2014 \|volume=9 \|issue=4 \|pages=e93905 \|doi=10.1371/journal.pone.0093905\|pmid=24714506 \|bibcode=2014PLoSO...993905S \|pmc=3979706 \|doi-access=free }}
	*{{Cite journal \|vauthors=Kumar P, Bhakuni DS, Rastogi S \|title=Diagnosis of Chlamydia trachomatis in patients with reactive arthritis and undifferentiated spondyloarthropathy \|journal= The Journal of Infection in Developing Countries\|date=2014 \|volume=8 \|issue=5 \|pages=648–654 \|doi=10.3855/jidc.3644\|pmid=24820470 \|doi-access=free }}		*{{Cite journal \|vauthors=Kumar P, Bhakuni DS, Rastogi S \|title=Diagnosis of Chlamydia trachomatis in patients with reactive arthritis and undifferentiated spondyloarthropathy \|journal= The Journal of Infection in Developing Countries\|date=2014 \|volume=8 \|issue=5 \|pages=648–654 \|doi=10.3855/jidc.3644\|pmid=24820470 \|doi-access=free }}

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{{Use dmy dates|date=May 2018}}
{{Use Indian English|date=May 2018}}
{{Infobox scientist
| name = Dewan Singh Bhakuni
| image =
| alt =
| caption =
| birth_date = {{Birth date and age|df=yes|1930|12|30}}
| birth_place = [[Uttar Pradesh]], India
| death_date =
| death_place =
| residence =
| nationality = [[Indian nationality|Indian]]
| fields = {{ublist | [[Natural product chemistry]] | [[Bioorganic chemistry]] }}
| workplaces = {{ublist | [[Central Drug Research Institute]] | [[National Botanical Research Institute]] | [[University of Concepción]] }}
| alma_mater = {{ublist | [[Allahabad University]] | [[Imperial College London]] | [[University of London]] }}
| doctoral_advisor = {{ublist | [[Sir Derek Barton]] }}
| doctoral_students =
| known_for = Studies on [[biogenesis]] of [[alkaloids]]
| awards = {{ublist | 1975 [[Shanti Swarup Bhatnagar Prize]] | 1988 Ranbaxy Research Award | 1989 Sir C. V. Raman Award | 2000 Acharya P. C. Ray Memorial Award }}
}}

'''Dewan Singh Bhakuni''' (born 1930) is an Indian [[natural product chemistry|natural product chemist]], [[Stereochemistry|stereochemist]] and a former director general-grade scientist of the [[Central Drug Research Institute]].<ref name="Popular Science Lecture on Drug Discovery">{{Cite web |url=http://www.nasi.nic.in/Lucknow%20Chapter.htm |title=Popular Science Lecture on "Drug Discovery" |date=2016 |publisher=National Academy of Sciences, India}}</ref> He is known for his researches on the [[biogenesis]] of [[alkaloids]]<ref name="Brief Profile of the Awardee">{{Cite web |url=http://ssbprize.gov.in/content/Detail.aspx?AID=398 |title=Brief Profile of the Awardee |date=2016 |publisher=Shanti Swarup Bhatnagar Prize |access-date=12 November 2016}}</ref> and is an elected fellow of the [[Indian Academy of Sciences]],<ref name="Fellow profile">{{Cite web |url=http://www.ias.ac.in/describe/fellow/Bhakuni,_Dr_Dewan_Singh |title=Fellow profile |date=2016 |publisher=Indian Academy of Sciences |access-date=12 November 2016}}</ref> the [[National Academy of Sciences, India]]<ref name="NASI Fellows">{{Cite web|url=http://www.nasi.org.in/fellows.asp?RsFilter=B |title=NASI Fellows |date=2016 |publisher=National Academy of Sciences, India |url-status=dead |archive-url=https://web.archive.org/web/20150717005033/http://www.nasi.org.in/fellows.asp?RsFilter=B |archive-date=2015-07-17 }}</ref> and the [[Indian National Science Academy]].<ref name="Indian fellow">{{Cite web |url=http://insaindia.res.in/detail.php?id=N79-0071 |title=Indian fellow |date=2016 |publisher=Indian National Science Academy |access-date=12 October 2016}}</ref> The [[Council of Scientific and Industrial Research]], the apex agency of the Government of India for scientific research, awarded him the [[Shanti Swarup Bhatnagar Prize for Science and Technology]], one of the highest Indian science awards, in 1975, for his contributions to chemical sciences.<ref name="View Bhatnagar Awardees">{{cite web | url=http://ssbprize.gov.in/Content/AwardeeList.aspx | title=View Bhatnagar Awardees | publisher=Shanti Swarup Bhatnagar Prize | date=2016 | access-date=12 November 2016}}</ref>

== Biography ==
[[File:Chattar Manzil 2005.jpg|thumb|235px|Central Drug Research Institute]]
D. S. Bhakuni, born on 30 December 1930 in the Indian state of [[Uttar Pradesh]], graduated in chemistry from [[Allahabad University]] and completed his master's degree at the same institution.<ref name="Indian fellow" /> He started his career in 1958 as a teaching faculty but a year later, joined [[Central Drug Research Institute]] (CDRI), Lucknow and worked there for three years. His next move was to [[National Botanical Research Institute]] in 1962 but later went to the UK to pursue his doctoral studies. He secured a Phd in 1965 from the [[University of London]] under the guidance of [[Sir Derek Barton]] of [[Imperial College London]], a renowned organic chemist and 1969 [[Nobel Prize for Chemistry|Nobel laureate]]; his thesis being ''Studies in alkaloid biosynthesis''.<ref name="Studies in alkaloid biosynthesis">{{Cite web |url=https://spiral.imperial.ac.uk/handle/10044/1/7139/browse?type=author&order=ASC&rpp=20&value=Bhakuni%2C+Dewan+Singh |title=Studies in alkaloid biosynthesis |date=2016 |publisher=University of London}}</ref> He would also receive the degree of Doctor of Science from London University in 1978. Returning to India, he joined CDRI in 1965 where he spent the rest of his official career till his superannuation in 1990 as a director general-grade scientist. In between, he had a stint at [[University of Concepción]], Chile as a visiting professor. Post-retirement, he was selected as an emeritus scientist by the [[Council of Scientific and Industrial Research]].<ref name="Indian fellow" />

== Legacy ==
Bhakuni, during the course of his active researches, studied the structure and stereochemistry of several indigenous plants and synthesized them for finding out the biologically active compounds; his work on the biogenesis of alkaloids was based on these examinations.<ref name="Handbook of Shanti Swarup Bhatnagar Prize Winners">{{cite web | url=http://www.csirhrdg.res.in/ssb.pdf | title=Handbook of Shanti Swarup Bhatnagar Prize Winners | publisher=Council of Scientific and Industrial Research | date=1999 | access-date=5 October 2016 | pages=34 | archive-url=https://web.archive.org/web/20160304043957/http://www.csirhrdg.res.in/ssb.pdf | archive-date=4 March 2016 | url-status=dead }}</ref> These studies are known to be pioneering studies on alkaloid biosynthesis and he developed a new methodology for determining the absolute configuration of alkaloids.<ref name="Indian fellow" /> Thus, he was able to identify the anti-cancer, anti-leishmanial, anti-viral and anti-allergic properties of a number of plants through mass spectrometric and [[Nuclear magnetic resonance spectroscopy]] techniques.<ref name="Indian fellow" />

Bhakuni has documented his researches in a book, ''Bioactive Marine Natural Products''<ref name="Bioactive Marine Natural Products">{{Cite book |title=Bioactive Marine Natural Products |last=Dewan S. Bhakuni, D.S. Rawat |publisher=Springer |year=2005 |isbn=978-1402034725 |page=382}}</ref> and over 300 articles published in peer-reviewed journals.{{Refn|group=note|Please see ''Selected bibliography'' section}} His writings have been cited by several authors{{Refn|group=note|Please see ''Citations'' section}} and he has mentored 40 doctoral scholars in their studies. A multidisciplinary program, under the title, ''Bioactive Substances from Indian Ocean'' was initiated by him during his days at the Central Drug Research Institute which is still active. He is a former president of the [[Indian Chemical Society]] (1996–97) and the Sectional Committee of [[Indian Science Congress Association]] (1994) and sat in the council of the Indian National Sciences Academy from 1982 to 1984.<ref name="Indian fellow" />

== Awards and honors ==
The [[Council of Scientific and Industrial Research]] awarded Bhakuni the [[Shanti Swarup Bhatnagar Prize]], one of the highest Indian science awards, in 1975.<ref name="Chemical Sciences">{{cite web | url=http://www.csir.res.in/External/Heads/career/award/BPRIZE/CHEMICAL_SCIENCES.htm | title=Chemical Sciences | publisher=Council of Scientific and Industrial Research | date=2016 | access-date=7 November 2016 | url-status=dead | archive-url=https://web.archive.org/web/20120912012851/http://www.csir.res.in/external/heads/career/award/BPRIZE/CHEMICAL_SCIENCES.htm | archive-date=12 September 2012 }}</ref> A [[University Grants Commission (India)|University Grants Commission]] National Lecturer (1982), he received the Ranbaxy Research Award in 1988 and Sir C. V. Raman Award in 1989.<ref name="Indian fellow" /> He is also a recipient of Acharya P. C. Ray Memorial Award which he received in 2000. He has delivered a number of award orations; Platinum Jubilee Lecture of [[Indian Science Congress Association]] (1993) and Dr R. C. Shah Memorial Lecture of [[Bombay University]] (1993) are some of the notable ones among them.<ref name="Indian fellow" /> He is an elected fellow of all the three major Indian science academies, [[Indian National Science Academy]], Indian Academy of Sciences<ref name="Indian fellow" /> and the [[National Academy of Sciences, India]].<ref name="NASI Fellows" />

== Citations ==
* {{cite book|author=M. F. Grundon|title=The Alkaloids|date=January 1983|publisher=Royal Society of Chemistry|isbn=978-0-85186-367-2|pages=40–}}
* {{cite book|author=R. B. Herbert|title=Biosynthesis|date=31 March 1989|publisher=Royal Society of Chemistry|isbn=978-0-85186-553-9|pages=220–}}
* {{cite book|title=Chemistry and Pharmacology|date=26 July 1996|publisher=Academic Press|isbn=978-0-08-086572-0|pages=334–}}
* {{cite book|author1=Dewan S. Bhakuni|author2=D.S. Rawat|title=Bioactive Marine Natural Products|date=30 June 2006|publisher=Springer|isbn=978-1-4020-3484-8|pages=101–}}
* {{cite book|author1=Dewan S. Bhakuni|author2=D.S. Rawat|title=Bioactive Marine Natural Products|date=30 June 2006|publisher=Springer|isbn=978-1-4020-3484-8|pages=234–}}
* {{cite book|author=Guenter Grethe|title=The Chemistry of Heterocyclic Compounds, Isoquinolines|date=15 September 2009|publisher=John Wiley & Sons|isbn=978-0-470-18862-0|pages=379–}}
* {{cite book|author1=Heiz Ellenberg|author2=Karl Esser|author3=Klaus Kubitzki, Eberhard Schnepf, Hubert Ziegler|title=Progress in Botany/Fortschritte der Botanik: Morphology · Physiology · Genetics Taxonomy · Geobotany / Morphologie · Physiologie · Genetik Systematik · Geobotanik|date=6 December 2012|publisher=Springer Science & Business Media|isbn=978-3-642-68297-1|pages=98–}}
* {{cite book|author=John Glasby|title=Encyclopedia of the Alkaloids|date=6 December 2012|publisher=Springer Science & Business Media|isbn=978-1-4615-9322-5|pages=101–}}
* {{cite book|author=S.W. Pelletier|title=Alkaloids: Chemical and Biological Perspectives|date=22 October 2013|publisher=Elsevier|isbn=978-1-4832-8784-3|pages=150–}}

== Selected bibliography ==

=== Books ===
* {{Cite book |title=Bioactive Marine Natural Products |last1=Bhakuni |first1=Dewan S. |last2=Rawat |first2=D. S. |publisher=Springer Netherlands |year=2006 |isbn=978-1-4020-3472-5}}

=== Articles ===
* {{Cite journal |author1=Dewan S. Bhakuni |author2=Awadhesh N. Singh |author3=Sudha Jain |title=Biosynthesis of isotetrandrine |journal=Tetrahedron |date=1980 |volume=36 |issue=14 |pages=2149–2151 |doi=10.1016/0040-4020(80)80107-4}}
* {{Cite journal |author1=PP Gupta |author2=RC Srimal |author3=K Avasthi |author4=N Garg |author5=T Chandra |author6=DS Bhakuni |title=Antiallergic activity of alkyl substituted pyrazolo [3, 4-d] pyrimidine (compound 88-765). |journal=Indian Journal of Experimental Biology |date=1995 |volume=33 |issue=1 |pages=38–40 |pmid=9135673}}
* {{Cite journal |vauthors=Biswas S, Sharma S, Saroha A, Bhakuni DS, Malhotra R, Zahur M, Oellerich M, Das HR, Asif AR |title=Identification of novel autoantigen in the synovial fluid of rheumatoid arthritis patients using an immunoproteomics approach |journal=PLOS ONE |date=2013 |volume=8 |issue=2 |pages=e56246 |doi=10.1371/journal.pone.0056246|pmid=23418544 |bibcode=2013PLoSO...856246B|pmc=3572018}}
* {{Cite journal |vauthors=Sharma S, Ghosh S, Singh LK, Sarkar A, Malhotra R, Garg OP, Singh Y, Sharma RS, Bhakuni DS, Das TK, Biswas S |title=Identification of autoantibodies against transthyretin for the screening and diagnosis of rheumatoid arthritis |journal=PLOS ONE |date=2014 |volume=9 |issue=4 |pages=e93905 |doi=10.1371/journal.pone.0093905|pmid=24714506 |bibcode=2014PLoSO...993905S |pmc=3979706 }}
*{{Cite journal |vauthors=Kumar P, Bhakuni DS, Rastogi S |title=Diagnosis of Chlamydia trachomatis in patients with reactive arthritis and undifferentiated spondyloarthropathy |journal= The Journal of Infection in Developing Countries|date=2014 |volume=8 |issue=5 |pages=648–654 |doi=10.3855/jidc.3644|pmid=24820470 |doi-access=free }}

== See also ==
* [[Sir Derek Barton]]
{{Portal|India|Chemistry}}

== Notes ==
{{Reflist|group=note}}

== References ==
{{Reflist}}

== External links ==
* {{Cite book |url=http://rushim.ru/books/biochemie/bioactive-marine-natural-products.pdf |title=Bioactive Marine Natural Products |last=D.S. Bhakuni, D.S. Rawat |publisher=Springer |work=Full text |location=2005}}
* {{Cite web |url=http://www.cdriindia.org/Awards.htm |title=Awards and Honors |date=2016 |publisher=Central Drug Research Institute |access-date=15 November 2016 |archive-url=https://web.archive.org/web/20161121174253/http://cdriindia.org/Awards.htm |archive-date=21 November 2016 |url-status=dead }}

{{SSBPST recipients in Chemical Science}}

{{Authority control}}

{{DEFAULTSORT:Bhakuni, Dewan Singh}}
[[Category:Recipients of the Shanti Swarup Bhatnagar Award in Chemical Science]]
[[Category:1930 births]]
[[Category:Scientists from Uttar Pradesh]]
[[Category:Indian organic chemists]]
[[Category:Indian scientific authors]]
[[Category:Alumni of the University of London]]
[[Category:Academics of Imperial College London]]
[[Category:University of Concepción faculty]]
[[Category:Council of Scientific and Industrial Research]]
[[Category:Fellows of the Indian Academy of Sciences]]
[[Category:Fellows of the Indian National Science Academy]]
[[Category:Fellows of The National Academy of Sciences, India]]
[[Category:University of Allahabad alumni]]
[[Category:Living people]]
[[Category:20th-century Indian chemists]]

Dewan Singh Bhakuni - Revision history

Birjesh Kumar: add section per sources and added references as per guidelines

CleanupBot II: Removed empty portal template using script

imported>Citation bot: Add: doi-access. | Use this bot. Report bugs. | Suggested by Headbomb | Linked from Wikipedia:WikiProject_Academic_Journals/Journals_cited_by_Wikipedia/Sandbox | #UCB_webform_linked 412/958

>Monkbot: Task 18 (cosmetic): eval 27 templates: del empty params (2×); hyphenate params (1×);