Asad Ullah Khan - Revision history

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{{short description|Indian microbiologist, biochemist, and professor}}
{{Use dmy dates|date=May 2018}}
{{Use Indian English|date=May 2018}}
{{Infobox scientist
| name = Asad Ullah Khan
| image =
| alt =
| caption =
| birth_date =
| birth_place = [[Badaun]], India
| death_date =
| death_place =
| fields = {{ublist | [[Biochemistry]] | [[Microbiology]] }}
| workplaces = {{ublist | [[Aligarh Muslim University]] }}
| alma_mater = {{ublist | [[Aligarh Muslim University]] | [[International Centre for Genetic Engineering and Biotechnology]] | [[Rutgers University]] }}
| doctoral_advisor =
| doctoral_students =
| known_for = Discovery of [[Aligarh super bug]] in India
| awards = {{ublist| 2020 [[Om Prakash Bhasin Award]] for Science and Technology | 2020  Visitor's award 2019 | 2014 [[Aligarh Muslim University|AMU]] Outstanding Research Award | 2012  [[National Bioscience Award for Career Development|N-BIOS Prize]] | 2011 [[Department of Biotechnology|DBT]] CREST Award | 2010 [[Aligarh Muslim University|AMU]] Active Teacher Award | 2009 AMI-ALEMBIC Award | 2006 AMI Young Scientist Award }}
}}
'''Asad Ullah Khan''' is an Indian microbiologist, biochemist and a professor at the Interdisciplinary Biotechnology Unit of the [[Aligarh Muslim University]]. He is known for his studies on [[multidrug resistant]] clinical [[Strain (biology)|strains]] as well as for the first sighting in India of [[Aligarh super bug]] (NDM-4), a variant of [[New Delhi metallo-beta-lactamase 1]] (NDM-1). He is an elected fellow of the [[Royal Society of Chemistry]], the Biotech Research Society, India and the Indian Academy of Microbiological Sciences. The [[Department of Biotechnology]] of the Government of India awarded him the [[National Bioscience Award for Career Development]], one of the highest Indian science awards, for his contributions to biosciences, in 2012.

== Biography ==
[[File:Babe seyad gate.jpg|thumb|Entrance to Aligarh Muslim University]]
Dr. Asad Ullah Khan did his undergraduate studies in chemistry and post-graduate studies in biotechnology at the [[Aligarh Muslim University]] (AMU) after which he pursued his doctoral studies at the [[International Centre for Genetic Engineering and Biotechnology]], [[New Delhi]] to secure a PhD in biochemistry from Aligarh Muslim University.<ref name="Asad U Khan Lab">{{Cite web |url=http://www.drasadlab.in/ |title=Asad U Khan Lab |date=2018-01-30 |website=Aligarh Muslim University India |language=en |access-date=2018-01-30}}</ref> He started his career as a lecturer at AMU in 1997 and during his career there, he did his post-doctoral studies at [[Rutgers University]] during 2000–03. He returned to India to resume his career at AMU where he holds the position of a professor and the coordinator of the Biotechnology Unit.<ref name="Aligarh Muslim University - Department Page">{{Cite web |url=https://www.amu.ac.in/dshowfacultydata.jsp?did=47&eid=10057753 |title=Aligarh Muslim University - Department Page |date=2018-01-30 |website=www.amu.ac.in |language=en |access-date=2018-01-30}}</ref>

== Professional profile ==
[[File:Klebsiella pneumoniae 01.png|thumb|right|''[[Klebsiella pneumoniae]]'', the bacterium in which [[NDM-1]] was first identified]]
Khan's research focus is on developing new inhibitors against [[multidrug resistant]] clinical [[Strain (biology)|strains]] with special interest on [[Extended-spectrum beta-lactamase|extended spectrum beta lactamases]] (ESBL) such as [[NDM-1]] and [[Beta-lactamase|CTX-M]], using QSARR modeling and structure-based virtual screening methods.<ref name="Asad U Khan Lab" /> The team led by him collect ''[[Escherichia coli]]'' and ''[[Klebsiella pneumoniae]]'' strains from hospital and community-acquired infection sites and it was during one of those explorations that he discovered a variant of [[New Delhi metallo-beta-lactamase 1]] named NDM-4, more commonly known as ''Aligarh super bug'', in the sewage drains of [[Jawaharlal Nehru Medical College, Aligarh]], in 2014.<ref name="Why India should be worried about the Aligarh superbug">{{Cite news |url=http://www.livemint.com/Politics/F9cXdam9j36xhzkegjZF3L/Why-India-should-be-worried-about-the-Aligarh-superbug.html |title=Why India should be worried about the Aligarh superbug |last=Krishnan |first=Vidya |date=2014-10-02 |work=Live Mint |access-date=2018-01-31}}</ref><ref>{{cite journal | doi=10.3329/bjms.v16i3.32842| last1= Rahman| first1= SZ | last2=Mishra| first2=A|title= Discovery of Aligarh Super Bug and Widespread variants of NDM1: A concern in antimicrobial resistance (Editorial)| journal= Bangladesh Journal of Medical Science |date=June 2017| volume= 16| issue=3 | pages= 335–336 | pmid=| s2cid=| doi-access=free}}</ref>This was the first recorded sighting of the antibiotic-resistant [[Super bug (bacteria)|super bug]] in India;{{Refn|group=note|[[New Delhi metallo-beta-lactamase 1]] was the first in the series of NDM super bugs and was detected in a Swedish patient in New Dehi in 2009,<ref>{{Cite journal |last1=Yong |first1=Dongeun |last2=Toleman |first2=Mark A. |last3=Giske |first3=Christian G. |last4=Cho |first4=Hyun S. |last5=Sundman |first5=Kristina |last6=Lee |first6=Kyungwon |last7=Walsh |first7=Timothy R. |date=2009-12-01 |title=Characterization of a New Metallo-β-Lactamase Gene, blaNDM-1, and a Novel Erythromycin Esterase Gene Carried on a Unique Genetic Structure in ''Klebsiella pneumoniae'' Sequence Type 14 from India |url= |journal=Antimicrobial Agents and Chemotherapy |language=en |volume=53 |issue=12 |pages=5046–5054 |doi=10.1128/aac.00774-09 |issn=0066-4804 |pmid=19770275|pmc=2786356 }}</ref>}}<ref name="New ‘superbug’ found in Aligarh hospital drain - Times of India">{{Cite news |url=https://timesofindia.indiatimes.com/city/agra/New-superbug-found-in-Aligarh-hospital-drain/articleshow/41811189.cms |title=New 'superbug' found in Aligarh hospital drain - Times of India |date=5 September 2014 |work=The Times of India |access-date=2018-01-31}}</ref><ref name="Antibiotic Resistant 'Super Bug' Found at Aligarh Muslim University">{{Cite news |url=https://www.ndtv.com/india-news/antibiotic-resistant-super-bug-found-at-aligarh-muslim-university-658368 |title=Antibiotic Resistant 'Super Bug' Found at Aligarh Muslim University |date=3 September 2014 |work=NDTV.com |access-date=2018-01-31}}</ref> the finding was later disclosed by Khan in an article published in the [[Journal of Medical Microbiology]].<ref name="Antibiotic resistant ‘superbug’ found at Aligarh medical college">{{Cite news |url=http://www.livemint.com/Politics/pBn6OceiarcL5LAy6HyweO/Antibiotic-resistant-super-bug-found-at-Aligarh-Muslim-Uni.html |title=Antibiotic resistant 'superbug' found at Aligarh medical college |last=PTI |date=2014-09-03 |work=Live Mint |access-date=2018-01-31}}</ref> Later, Khan and his colleagues developed a protocol for detecting super bugs and was successful in sequencing the genes of three variants of NDM-1.<ref name="AMU scientists ‘develop' technique to detect superbug">{{Cite news |url=http://www.thehindu.com/todays-paper/tp-national/tp-newdelhi/amu-scientists-develop-technique-to-detect-superbug/article2092742.ece |title=AMU scientists 'develop' technique to detect superbug |date=2011-06-10 |work=The Hindu |access-date=2018-01-31 |language=en-IN |issn=0971-751X}}</ref> His studies have been documented by way of a number of articles<ref name="On Google Scholar">{{Cite web |url=https://scholar.google.co.in/citations?user=h5isISAAAAAJ |title=On Google Scholar |date=2018-01-30 |publisher=Google Scholar |access-date=2018-01-30}}</ref>{{Refn|group=note|Please see ''Selected bibliography'' section}} and [[ResearchGate]], an online repository of scientific articles has listed 241 of them.<ref name="On ResearchGate">{{Cite web |url=https://www.researchgate.net/profile/Asad_Khan17 |title=On ResearchGate |date=2018-01-30 |access-date=2018-01-30}}</ref> Besides he has also edited three books.<ref name="Aligarh Muslim University - Department Page" />
Khan is a member of the scientific committee of the Indian Academy of Biomedical Sciences<ref name="Welcome to :: Indian Academy of Biomedical Sciences (IABS) - Uttar Pradesh, India">{{Cite web |url=http://iabs.in/conf-alig-14-15-dec.2013.htm |title=Welcome to :: Indian Academy of Biomedical Sciences (IABS) - Uttar Pradesh, India |date=2018-01-30 |website=iabs.in |access-date=2018-01-30 |archive-url=https://web.archive.org/web/20170608061513/http://iabs.in/conf-alig-14-15-dec.2013.htm |archive-date=8 June 2017 |url-status=dead |df=dmy-all }}</ref> and sits in the advisory board of the Sir Syed Global Scholar Award (SSGSA) committee.<ref name="Sir Syed Global Scholar Award (SSESA)">{{Cite web |url=http://www.ssgsa.us/members.php |title=Sir Syed Global Scholar Award (SSESA) |date=2018-01-30 |website=www.ssgsa.us |access-date=2018-01-30}}</ref> He is an associate editor of [[BMC Microbiology]] for their section on Clinical microbiology and vaccines<ref name="BMC Microbiology">{{Cite web |url=https://bmcmicrobiol.biomedcentral.com/about/editorial-board |title=BMC Microbiology |date=2018-01-31 |website=BMC Microbiology |language=en |access-date=2018-01-31}}</ref> and is a member of the Task Force on Bioinformatics, Computational and Systems Biology of the [[Department of Biotechnology]].<ref name="Aligarh Muslim University - Department Page" /> He has also conducted workshops and seminars on the subject.<ref name="Centre For Sophisticated Instruments Facility AMU Organises Workshop On Flow Cytometry and Its Applications">{{Cite web |url=http://myamu.in/news/centre-sophisticated-instruments-facility-amu-organises-workshop-flow-cytometry-and-its |title=Centre For Sophisticated Instruments Facility AMU Organises Workshop On Flow Cytometry and Its Applications |date=2018-01-31 |website=myamu.in |language=en |access-date=2018-01-31}}</ref>

== Awards and honors ==
Recipient of Sri Om Prakash Bhasin Award-2019 and visitor's Award 2019 for his trail-blazing research in Biotechnology; The Association of Microbiologists of India (AMI) awarded Khan the Young Scientist Award in 2006;<ref name="Aligarh Muslim University - Department Page" /> AMI honored him again in 2009 with the Alembic Award.<ref name="Awardees - Association of Microbiologists of India">{{Cite web |url=http://www.amiindia.info/awardees.php |title=Awardees - Association of Microbiologists of India |date=2018-01-31 |website=www.amiindia.info |language=en |access-date=2018-01-31}}</ref><ref name="Dr Asadullah Khan Awarded AMI-ALEMBIC Award of 2009">{{Cite web |url=http://amunewsandviews.blogspot.ae/2009/12/dr-asadullah-khan-awarded-ami-alembic.html |title=Dr Asadullah Khan Awarded AMI-ALEMBIC Award of 2009 |date=2018-01-31 |website=amunewsandviews.blogspot.ae |access-date=2018-01-31}}</ref> He received the Most Active Teacher Award from Aligarh Muslim University in 2010<ref name="Distinguished AMU research scholars, teachers and students honored">{{Cite web |url=http://www.ummid.com/news/2010/January/27.01.2010/amu_vc_awards_distinguished_faculties.htm |title=Distinguished AMU research scholars, teachers and students honored |last=Reporter |first=ummid.com Staff |website=www.ummid.com |access-date=2018-01-31}}</ref> and the Cutting-Edge Research Enhancement and Scientific Training (CREST) Award of the Department of Biotechnology in 2011.<ref name="Aligarh Muslim University - Department Page" /> The [[Department of Biotechnology]] (DBT) of the Government of India awarded him the [[National Bioscience Award for Career Development]], one of the highest Indian science awards in 2012.<ref name="Awardees of National Bioscience Awards for Career Development">{{Cite web |url=http://dbtindia.nic.in/wp-content/uploads/2014/03/list_of_bioscience_awardees.pdf |title=Awardees of National Bioscience Awards for Career Development |date=2016 |publisher=Department of Biotechnology |access-date=2017-11-20}}</ref> When Aligarh Muslim University instituted the Outstanding Research Award in 2014, he was the first recipient of the award.<ref name="National Fellowships and Awards">{{Cite web |url=http://www.drasadlab.in/credentials/awards |title=National Fellowships and Awards |date=2018-01-31 |website=Interdisciplinary Biotechnology Unit Aligarh Muslim University India |language=en |access-date=2018-01-31}}</ref>

Khan was elected as a fellow by the Royal Society of Chemistry in 2017.<ref name="AMU Faculty elected as Fellow of Royal Society of Chemistry">{{Cite web |url=http://twocircles.net/2017nov18/418417.html |title=AMU Faculty elected as Fellow of Royal Society of Chemistry |date=18 November 2017 |website=Two Circles |language=en-US |access-date=2018-01-31}}</ref> He is also an elected fellow of the Biotech Research Society, India<ref name="Fellows of BRSI">{{Cite web |url=http://www.brsi.in/fellows |title=Fellows of BRSI |date=2018-01-31 |website=The Biotech Research Society, India |language=en-US |access-date=2018-01-31}}</ref> and the Indian Academy of Microbiological Sciences<ref name="AMI Fellows">{{Cite web |url=http://www.amiindia.info/fellows.php |title=AMI Fellows |date=2018-01-31 |website=Association of Microbiologists of India |language=en |access-date=2018-01-31}}</ref> and the various research fellowships he has received include [[University Grants Commission (India)|University Grants Commission]] fellowship (1995–98), Boyscast fellowship of the [[Department of Science and Technology (India)|Department of Science and Technology]] (2004–05) and the visiting fellowship of the [[Indian National Science Academy]] (2006–07).<ref name="National Fellowships and Awards" />

== Selected bibliography ==
* {{cite journal |doi=10.3389/fimmu.2017.01552 |pmid=29181009 |pmc=5694031 |title=CRISPRi Induced Suppression of Fimbriae Gene (fimH) of a Uropathogenic Escherichia coli: An Approach to Inhibit Microbial Biofilms |journal=Frontiers in Immunology |volume=8 |pages=1552 |year=2017 |last1=Zuberi |first1=Azna |last2=Ahmad |first2=Nayeem |last3=Khan |first3=Asad U }}
* {{cite journal |doi=10.1038/s41598-017-09588-1 |pmid=28835636 |pmc=5569068 |title=Potential inhibitors designed against NDM-1 type metallo-β-lactamases: An attempt to enhance efficacies of antibiotics against multi-drug-resistant bacteria |journal=Scientific Reports |volume=7 |issue=1 |pages=9207 |year=2017 |last1=Khan |first1=Asad U |last2=Ali |first2=Abid |last3=Danishuddin |last4=Srivastava |first4=Gaurava |last5=Sharma |first5=Ashok |bibcode=2017NatSR...7.9207K }}
* {{cite journal |doi=10.1016/j.nano.2017.06.015 |pmid=28673854 |title=Nano-therapeutics: A revolution in infection control in post antibiotic era |journal=Nanomedicine: Nanotechnology, Biology and Medicine |volume=13 |issue=7 |pages=2281–2301 |year=2017 |last1=Zaidi |first1=Sahar |last2=Misba |first2=Lama |last3=Khan |first3=Asad U }}
* {{cite journal |doi=10.3389/fcimb.2017.00214 |pmid=28603699 |pmc=5445563 |title=CRISPR Interference (CRISPRi) Inhibition of luxS Gene Expression in E. Coli: An Approach to Inhibit Biofilm |journal=Frontiers in Cellular and Infection Microbiology |volume=7 |pages=214 |year=2017 |last1=Zuberi |first1=Azna |last2=Misba |first2=Lama |last3=Khan |first3=Asad U }}
* {{cite journal |doi=10.1016/j.ijantimicag.2016.10.001 |pmid=28244375 |title=First reported New Delhi metallo-β-lactamase-1-producing Cedecea lapagei |journal=International Journal of Antimicrobial Agents |volume=49 |issue=1 |pages=118–119 |year=2017 |last1=Ahmad |first1=Nayeem |last2=Ali |first2=Syed Manazir |last3=Khan |first3=Asad U }}
* {{cite journal |doi=10.1016/S1473-3099(15)00424-7 |pmid=26603172 |title=Emergence of plasmid-mediated colistin resistance mechanism MCR-1 in animals and human beings in China: A microbiological and molecular biological study |journal=The Lancet Infectious Diseases |volume=16 |issue=2 |pages=161–168 |year=2016 |last1=Liu |first1=Yi-Yun |last2=Wang |first2=Yang |last3=Walsh |first3=Timothy R |last4=Yi |first4=Ling-Xian |last5=Zhang |first5=Rong |last6=Spencer |first6=James |last7=Doi |first7=Yohei |last8=Tian |first8=Guobao |last9=Dong |first9=Baolei |last10=Huang |first10=Xianhui |last11=Yu |first11=Lin-Feng |last12=Gu |first12=Danxia |last13=Ren |first13=Hongwei |last14=Chen |first14=Xiaojie |last15=Lv |first15=Luchao |last16=He |first16=Dandan |last17=Zhou |first17=Hongwei |last18=Liang |first18=Zisen |last19=Liu |first19=Jian-Hua |last20=Shen |first20=Jianzhong }}
* {{cite journal |doi=10.1016/j.drudis.2016.06.013 |pmid=27326911 |title=Descriptors and their selection methods in QSAR analysis: Paradigm for drug design |journal=Drug Discovery Today |volume=21 |issue=8 |pages=1291–1302 |year=2016 |last1=Danishuddin |last2=Khan |first2=Asad U }}
* {{cite journal |doi=10.1128/AAC.01194-15 |pmid=26525789 |title=Role of Non-Active-Site Residue Trp-93 in the Function and Stability of New Delhi Metallo-β-Lactamase 1 |journal=Antimicrobial Agents and Chemotherapy |volume=60 |issue=1 |pages=356–360 |year=2016 |last1=Khan |first1=Asad U |last2=Rehman |first2=M. Tabish |pmc=4704196 }}
* {{cite journal |doi=10.3389/fmicb.2016.00174 |pmid=26925046 |pmc=4757689 |title=Breaking the Spell: Combating Multidrug Resistant 'Superbugs' |journal=Frontiers in Microbiology |volume=7 |pages=174 |year=2016 |last1=Khan |first1=Shahper N |last2=Khan |first2=Asad U }}
* {{cite journal |doi=10.1021/mp500116c |pmid=24745377 |title=Insight into the Binding Mechanism of Imipenem to Human Serum Albumin by Spectroscopic and Computational Approaches |journal=Molecular Pharmaceutics |volume=11 |issue=6 |pages=1785–1797 |year=2014 |last1=Rehman |first1=Md Tabish |last2=Shamsi |first2=Hira |last3=Khan |first3=Asad U |url=https://figshare.com/articles/journal_contribution/Insight_into_the_Binding_Mechanism_of_Imipenem_to_Human_Serum_Albumin_by_Spectroscopic_and_Computational_Approaches/2287498 }}
* {{cite journal |doi=10.1186/s12866-014-0320-5 |pmid=25591663 |pmc=4316655 |title=Inhibitory effect of zingiber officinale towards Streptococcus mutans virulence and caries development: In vitro and in vivo studies |journal=BMC Microbiology |volume=15 |pages=1 |year=2015 |last1=Hasan |first1=Sadaf |last2=Danishuddin |first2=Mohd |last3=Khan |first3=Asad U }}
* {{cite journal |doi=10.1016/j.ymeth.2014.10.019 |pmid=25448480 |title=Structure based virtual screening to discover putative drug candidates: Necessary considerations and successful case studies |journal=Methods |volume=71 |pages=135–145 |year=2015 |last1=Danishuddin |first1=Mohd |last2=Khan |first2=Asad U }}
* {{cite journal |doi=10.1186/s12866-014-0320-5|pmid=25591663|pmc=4316655|title=Inhibitory effect of zingiber officinale towards Streptococcus mutans virulence and caries development: In vitro and in vivo studies|journal=BMC Microbiology|volume=15|pages=1|year=2015|last1=Hasan|first1=Sadaf|last2=Danishuddin|first2=Mohd|last3=Khan|first3=Asad U}}
* {{cite journal |doi=10.1080/08927014.2014.983093 |pmid=25431994 |title=A graphene/zinc oxide nanocomposite film protects dental implant surfaces against cariogenic ''Streptococcus'' mutans |journal=Biofouling |volume=30 |issue=10 |pages=1281–1294 |year=2014 |last1=Kulshrestha |first1=Shatavari |last2=Khan |first2=Shakir |last3=Meena |first3=Ramovatar |last4=Singh |first4=Braj R |last5=Khan |first5=Asad U |s2cid=205606245 }}
* {{cite journal |doi=10.2147/IJN.S31219 |pmid=22802686 |pmc=3396389 |title=Gold nanoparticles enhance methylene blue– induced photodynamic therapy: A novel therapeutic approach to inhibit Candida albicans biofilm |journal=International Journal of Nanomedicine |volume=7 |pages=3245–57 |year=2012 |last1=Khan |first1=Asad |last2=Khan |last3=Azam |last4=Alam }}
* {{cite journal |doi=10.1371/journal.pone.0091736 |pmid=24622055 |pmc=3951425 |title=Inhibition of Major Virulence Pathways of Streptococcus mutans by Quercitrin and Deoxynojirimycin: A Synergistic Approach of Infection Control |journal=PLOS ONE |volume=9 |issue=3 |pages=e91736 |year=2014 |last1=Hasan |first1=Sadaf |last2=Singh |first2=Kunal |last3=Danisuddin |first3=Mohd |last4=Verma |first4=Praveen K |last5=Khan |first5=Asad U |bibcode=2014PLoSO...991736H }}
* {{cite journal |doi=10.1371/journal.pone.0056926 |pmid=23437273 |pmc=3578935 |title=Biochemical Characterization of CTX-M-15 from Enterobacter cloacae and Designing a Novel Non-β-Lactam-β-Lactamase Inhibitor |journal=PLOS ONE |volume=8 |issue=2 |pages=e56926 |year=2013 |last1=Faheem |first1=Mohammad |last2=Rehman |first2=Md Tabish |last3=Danishuddin |first3=Mohd |last4=Khan |first4=Asad U |bibcode=2013PLoSO...856926F }}
* {{cite journal |doi=10.1371/journal.pone.0051850 |pmid=23251640 |pmc=3522591 |title=Inhibition of N-Terminal Lysines Acetylation and Transcription Factor Assembly by Epirubicin Induced Deranged Cell Homeostasis |journal=PLOS ONE |volume=7 |issue=12 |pages=e51850 |year=2012 |last1=Khan |first1=Shahper N |last2=Danishuddin |first2=Mohd |last3=Varshney |first3=Bhavna |last4=Lal |first4=Sunil K |last5=Khan |first5=Asad U |bibcode=2012PLoSO...751850K }}
* {{cite journal |doi=10.1093/jac/dkn253 |pmid=18565974 |title=Novel anti-adherence activity of mulberry leaves: Inhibition of Streptococcus mutans biofilm by 1-deoxynojirimycin isolated from Morus alba |journal=Journal of Antimicrobial Chemotherapy |volume=62 |issue=4 |pages=751–757 |year=2008 |last1=Islam |first1=B |last2=Khan |first2=S. N |last3=Haque |first3=I |last4=Alam |first4=M |last5=Mushfiq |first5=M |last6=Khan |first6=A. U |doi-access=free }}
* {{cite journal |doi=10.1128/AAC.00366-08 |pmid=18725447 |pmc=2573143 |title=A Plasmid-Borne blaOXA-58 Gene Confers Imipenem Resistance to Acinetobacter baumannii Isolates from a Lebanese Hospital |journal=Antimicrobial Agents and Chemotherapy |volume=52 |issue=11 |pages=4115–4120 |year=2008 |last1=Zarrilli |first1=R |last2=Vitale |first2=D |last3=Di Popolo |first3=A |last4=Bagattini |first4=M |last5=Daoud |first5=Z |last6=Khan |first6=A. U |last7=Afif |first7=C |last8=Triassi |first8=M }}
* {{cite journal |doi=10.1101/gad.1075203 |pmid=12704082 |pmc=196040 |title=Functional interactions between the transcription and mRNA 3' end processing machineries mediated by Ssu72 and Sub1 |journal=Genes & Development |volume=17 |issue=8 |pages=1030–1042 |year=2003 |last1=He |first1=X }}
* {{cite journal |doi=10.1016/S0168-9525(02)02746-4 |title=Connecting the DOTs: Covalent histone modifications and the formation of silent chromatin |journal=Trends in Genetics |volume=18 |issue=8 |pages=387–389 |year=2002 |last1=Khan |first1=Asad U |last2=Hampsey |first2=Michael |pmid=12142001 }}

== See also ==
{{Div col|colwidth=30em}}
* [[New Delhi metallo-beta-lactamase 1]]
* [[Multiple drug resistance#Common multidrug-resistant organisms (MDROs)|Common multidrug-resistant organisms (MDROs)]]
{{Div col end}}
{{portal|India|Biology|Medicine}}

== Notes ==
{{reflist|group=note}}

== References ==
{{reflist}}

== Further reading ==
* {{Cite journal |last=Rahman SZ , Mishra A |title=Discovery of Aligarh Super Bug and Widespread variants of NDM1: A concern in antimicrobial resistance |url=https://www.banglajol.info/index.php/BJMS/article/viewFile/32842/22189 |journal=Bangladesh Journal of Medical Science |date=9 June 2017 |volume=16 |issue=3 |pages=335–336 |doi=10.3329/bjms.v16i3.32842 |doi-access=free }}

== External links ==
* {{Cite web |url=http://www.educationanalysis.in/news/national-symposium-cum-bioinformatics-workshop-at-amu |title=National Symposium cum Bioinformatics Workshop at AMU |date=25 March 2015 |website=www.educationanalysis.in |language=en-US |access-date=2018-01-31 |archive-url=https://web.archive.org/web/20180131140911/http://www.educationanalysis.in/news/national-symposium-cum-bioinformatics-workshop-at-amu |archive-date=31 January 2018 |url-status=dead |df=dmy-all }}
* {{Cite news |url=http://www.indiatomorrow.net/eng/aligarh-scientists-discover-new-superbug |title=Aligarh scientists discover new superbug |date=6 September 2014 |work=India Tomorrow |access-date=2018-01-31}}
* {{Cite news |url=http://www.healthcareasia.org/2014/new-strain-of-superbug-discovered-by-aligarh-researchers/ |title=New strain of superbug discovered by Aligarh researchers |date=9 September 2014 |work=Healthcare Asia |access-date=2018-01-31}}

{{N-BIOS Laureates 2010–2019}}
{{authority control}}

{{DEFAULTSORT:Khan, Asad Ullah}}
[[Category:N-BIOS Prize recipients]]
[[Category:Indian scientific authors]]
[[Category:Living people]]
[[Category:21st-century Indian biologists]]
[[Category:Indian medical researchers]]
[[Category:Indian microbiologists]]
[[Category:Scientists from Uttar Pradesh]]
[[Category:Year of birth missing (living people)]]
[[Category:Fellows of the Royal Society of Chemistry]]
[[Category:Aligarh Muslim University alumni]]
[[Category:Aligarh Muslim University faculty]]
[[Category:Rutgers University alumni]]
[[Category:Indian biochemists]]

← Older revision		Revision as of 08:07, 20 August 2021
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	== Selected bibliography ==		== Selected bibliography ==
	* {{cite journal \|doi=10.3389/fimmu.2017.01552 \|pmid=29181009 \|pmc=5694031 \|title=CRISPRi Induced Suppression of Fimbriae Gene (fimH) of a Uropathogenic Escherichia coli: An Approach to Inhibit Microbial Biofilms \|journal=Frontiers in Immunology \|volume=8 \|pages=1552 \|year=2017 \|last1=Zuberi \|first1=Azna \|last2=Ahmad \|first2=Nayeem \|last3=Khan \|first3=Asad U }}		* {{cite journal \|doi=10.3389/fimmu.2017.01552 \|pmid=29181009 \|pmc=5694031 \|title=CRISPRi Induced Suppression of Fimbriae Gene (fimH) of a Uropathogenic Escherichia coli: An Approach to Inhibit Microbial Biofilms \|journal=Frontiers in Immunology \|volume=8 \|pages=1552 \|year=2017 \|last1=Zuberi \|first1=Azna \|last2=Ahmad \|first2=Nayeem \|last3=Khan \|first3=Asad U \|doi-access=free }}
	* {{cite journal \|doi=10.1038/s41598-017-09588-1 \|pmid=28835636 \|pmc=5569068 \|title=Potential inhibitors designed against NDM-1 type metallo-β-lactamases: An attempt to enhance efficacies of antibiotics against multi-drug-resistant bacteria \|journal=Scientific Reports \|volume=7 \|issue=1 \|pages=9207 \|year=2017 \|last1=Khan \|first1=Asad U \|last2=Ali \|first2=Abid \|last3=Danishuddin \|last4=Srivastava \|first4=Gaurava \|last5=Sharma \|first5=Ashok \|bibcode=2017NatSR...7.9207K }}		* {{cite journal \|doi=10.1038/s41598-017-09588-1 \|pmid=28835636 \|pmc=5569068 \|title=Potential inhibitors designed against NDM-1 type metallo-β-lactamases: An attempt to enhance efficacies of antibiotics against multi-drug-resistant bacteria \|journal=Scientific Reports \|volume=7 \|issue=1 \|pages=9207 \|year=2017 \|last1=Khan \|first1=Asad U \|last2=Ali \|first2=Abid \|last3=Danishuddin \|last4=Srivastava \|first4=Gaurava \|last5=Sharma \|first5=Ashok \|bibcode=2017NatSR...7.9207K }}
	* {{cite journal \|doi=10.1016/j.nano.2017.06.015 \|pmid=28673854 \|title=Nano-therapeutics: A revolution in infection control in post antibiotic era \|journal=Nanomedicine: Nanotechnology, Biology and Medicine \|volume=13 \|issue=7 \|pages=2281–2301 \|year=2017 \|last1=Zaidi \|first1=Sahar \|last2=Misba \|first2=Lama \|last3=Khan \|first3=Asad U }}		* {{cite journal \|doi=10.1016/j.nano.2017.06.015 \|pmid=28673854 \|title=Nano-therapeutics: A revolution in infection control in post antibiotic era \|journal=Nanomedicine: Nanotechnology, Biology and Medicine \|volume=13 \|issue=7 \|pages=2281–2301 \|year=2017 \|last1=Zaidi \|first1=Sahar \|last2=Misba \|first2=Lama \|last3=Khan \|first3=Asad U }}
	* {{cite journal \|doi=10.3389/fcimb.2017.00214 \|pmid=28603699 \|pmc=5445563 \|title=CRISPR Interference (CRISPRi) Inhibition of luxS Gene Expression in E. Coli: An Approach to Inhibit Biofilm \|journal=Frontiers in Cellular and Infection Microbiology \|volume=7 \|pages=214 \|year=2017 \|last1=Zuberi \|first1=Azna \|last2=Misba \|first2=Lama \|last3=Khan \|first3=Asad U }}		* {{cite journal \|doi=10.3389/fcimb.2017.00214 \|pmid=28603699 \|pmc=5445563 \|title=CRISPR Interference (CRISPRi) Inhibition of luxS Gene Expression in E. Coli: An Approach to Inhibit Biofilm \|journal=Frontiers in Cellular and Infection Microbiology \|volume=7 \|pages=214 \|year=2017 \|last1=Zuberi \|first1=Azna \|last2=Misba \|first2=Lama \|last3=Khan \|first3=Asad U \|doi-access=free }}
	* {{cite journal \|doi=10.1016/j.ijantimicag.2016.10.001 \|pmid=28244375 \|title=First reported New Delhi metallo-β-lactamase-1-producing Cedecea lapagei \|journal=International Journal of Antimicrobial Agents \|volume=49 \|issue=1 \|pages=118–119 \|year=2017 \|last1=Ahmad \|first1=Nayeem \|last2=Ali \|first2=Syed Manazir \|last3=Khan \|first3=Asad U }}		* {{cite journal \|doi=10.1016/j.ijantimicag.2016.10.001 \|pmid=28244375 \|title=First reported New Delhi metallo-β-lactamase-1-producing Cedecea lapagei \|journal=International Journal of Antimicrobial Agents \|volume=49 \|issue=1 \|pages=118–119 \|year=2017 \|last1=Ahmad \|first1=Nayeem \|last2=Ali \|first2=Syed Manazir \|last3=Khan \|first3=Asad U }}
	* {{cite journal \|doi=10.1016/S1473-3099(15)00424-7 \|pmid=26603172 \|title=Emergence of plasmid-mediated colistin resistance mechanism MCR-1 in animals and human beings in China: A microbiological and molecular biological study \|journal=The Lancet Infectious Diseases \|volume=16 \|issue=2 \|pages=161–168 \|year=2016 \|last1=Liu \|first1=Yi-Yun \|last2=Wang \|first2=Yang \|last3=Walsh \|first3=Timothy R \|last4=Yi \|first4=Ling-Xian \|last5=Zhang \|first5=Rong \|last6=Spencer \|first6=James \|last7=Doi \|first7=Yohei \|last8=Tian \|first8=Guobao \|last9=Dong \|first9=Baolei \|last10=Huang \|first10=Xianhui \|last11=Yu \|first11=Lin-Feng \|last12=Gu \|first12=Danxia \|last13=Ren \|first13=Hongwei \|last14=Chen \|first14=Xiaojie \|last15=Lv \|first15=Luchao \|last16=He \|first16=Dandan \|last17=Zhou \|first17=Hongwei \|last18=Liang \|first18=Zisen \|last19=Liu \|first19=Jian-Hua \|last20=Shen \|first20=Jianzhong }}		* {{cite journal \|doi=10.1016/S1473-3099(15)00424-7 \|pmid=26603172 \|title=Emergence of plasmid-mediated colistin resistance mechanism MCR-1 in animals and human beings in China: A microbiological and molecular biological study \|journal=The Lancet Infectious Diseases \|volume=16 \|issue=2 \|pages=161–168 \|year=2016 \|last1=Liu \|first1=Yi-Yun \|last2=Wang \|first2=Yang \|last3=Walsh \|first3=Timothy R \|last4=Yi \|first4=Ling-Xian \|last5=Zhang \|first5=Rong \|last6=Spencer \|first6=James \|last7=Doi \|first7=Yohei \|last8=Tian \|first8=Guobao \|last9=Dong \|first9=Baolei \|last10=Huang \|first10=Xianhui \|last11=Yu \|first11=Lin-Feng \|last12=Gu \|first12=Danxia \|last13=Ren \|first13=Hongwei \|last14=Chen \|first14=Xiaojie \|last15=Lv \|first15=Luchao \|last16=He \|first16=Dandan \|last17=Zhou \|first17=Hongwei \|last18=Liang \|first18=Zisen \|last19=Liu \|first19=Jian-Hua \|last20=Shen \|first20=Jianzhong }}
	* {{cite journal \|doi=10.1016/j.drudis.2016.06.013 \|pmid=27326911 \|title=Descriptors and their selection methods in QSAR analysis: Paradigm for drug design \|journal=Drug Discovery Today \|volume=21 \|issue=8 \|pages=1291–1302 \|year=2016 \|last1=Danishuddin \|last2=Khan \|first2=Asad U }}		* {{cite journal \|doi=10.1016/j.drudis.2016.06.013 \|pmid=27326911 \|title=Descriptors and their selection methods in QSAR analysis: Paradigm for drug design \|journal=Drug Discovery Today \|volume=21 \|issue=8 \|pages=1291–1302 \|year=2016 \|last1=Danishuddin \|last2=Khan \|first2=Asad U }}
	* {{cite journal \|doi=10.1128/AAC.01194-15 \|pmid=26525789 \|title=Role of Non-Active-Site Residue Trp-93 in the Function and Stability of New Delhi Metallo-β-Lactamase 1 \|journal=Antimicrobial Agents and Chemotherapy \|volume=60 \|issue=1 \|pages=356–360 \|year=2016 \|last1=Khan \|first1=Asad U \|last2=Rehman \|first2=M. Tabish \|pmc=4704196 }}		* {{cite journal \|doi=10.1128/AAC.01194-15 \|pmid=26525789 \|title=Role of Non-Active-Site Residue Trp-93 in the Function and Stability of New Delhi Metallo-β-Lactamase 1 \|journal=Antimicrobial Agents and Chemotherapy \|volume=60 \|issue=1 \|pages=356–360 \|year=2016 \|last1=Khan \|first1=Asad U \|last2=Rehman \|first2=M. Tabish \|pmc=4704196 }}
	* {{cite journal \|doi=10.3389/fmicb.2016.00174 \|pmid=26925046 \|pmc=4757689 \|title=Breaking the Spell: Combating Multidrug Resistant 'Superbugs' \|journal=Frontiers in Microbiology \|volume=7 \|pages=174 \|year=2016 \|last1=Khan \|first1=Shahper N \|last2=Khan \|first2=Asad U }}		* {{cite journal \|doi=10.3389/fmicb.2016.00174 \|pmid=26925046 \|pmc=4757689 \|title=Breaking the Spell: Combating Multidrug Resistant 'Superbugs' \|journal=Frontiers in Microbiology \|volume=7 \|pages=174 \|year=2016 \|last1=Khan \|first1=Shahper N \|last2=Khan \|first2=Asad U \|doi-access=free }}
	* {{cite journal \|doi=10.1021/mp500116c \|pmid=24745377 \|title=Insight into the Binding Mechanism of Imipenem to Human Serum Albumin by Spectroscopic and Computational Approaches \|journal=Molecular Pharmaceutics \|volume=11 \|issue=6 \|pages=1785–1797 \|year=2014 \|last1=Rehman \|first1=Md Tabish \|last2=Shamsi \|first2=Hira \|last3=Khan \|first3=Asad U \|url=https://figshare.com/articles/journal_contribution/Insight_into_the_Binding_Mechanism_of_Imipenem_to_Human_Serum_Albumin_by_Spectroscopic_and_Computational_Approaches/2287498 }}		* {{cite journal \|doi=10.1021/mp500116c \|pmid=24745377 \|title=Insight into the Binding Mechanism of Imipenem to Human Serum Albumin by Spectroscopic and Computational Approaches \|journal=Molecular Pharmaceutics \|volume=11 \|issue=6 \|pages=1785–1797 \|year=2014 \|last1=Rehman \|first1=Md Tabish \|last2=Shamsi \|first2=Hira \|last3=Khan \|first3=Asad U \|url=https://figshare.com/articles/journal_contribution/Insight_into_the_Binding_Mechanism_of_Imipenem_to_Human_Serum_Albumin_by_Spectroscopic_and_Computational_Approaches/2287498 }}
	* {{cite journal \|doi=10.1186/s12866-014-0320-5 \|pmid=25591663 \|pmc=4316655 \|title=Inhibitory effect of zingiber officinale towards Streptococcus mutans virulence and caries development: In vitro and in vivo studies \|journal=BMC Microbiology \|volume=15 \|pages=1 \|year=2015 \|last1=Hasan \|first1=Sadaf \|last2=Danishuddin \|first2=Mohd \|last3=Khan \|first3=Asad U }}		* {{cite journal \|doi=10.1186/s12866-014-0320-5 \|pmid=25591663 \|pmc=4316655 \|title=Inhibitory effect of zingiber officinale towards Streptococcus mutans virulence and caries development: In vitro and in vivo studies \|journal=BMC Microbiology \|volume=15 \|pages=1 \|year=2015 \|last1=Hasan \|first1=Sadaf \|last2=Danishuddin \|first2=Mohd \|last3=Khan \|first3=Asad U }}
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	* {{cite journal \|doi=10.1080/08927014.2014.983093 \|pmid=25431994 \|title=A graphene/zinc oxide nanocomposite film protects dental implant surfaces against cariogenic ''Streptococcus'' mutans \|journal=Biofouling \|volume=30 \|issue=10 \|pages=1281–1294 \|year=2014 \|last1=Kulshrestha \|first1=Shatavari \|last2=Khan \|first2=Shakir \|last3=Meena \|first3=Ramovatar \|last4=Singh \|first4=Braj R \|last5=Khan \|first5=Asad U \|s2cid=205606245 }}		* {{cite journal \|doi=10.1080/08927014.2014.983093 \|pmid=25431994 \|title=A graphene/zinc oxide nanocomposite film protects dental implant surfaces against cariogenic ''Streptococcus'' mutans \|journal=Biofouling \|volume=30 \|issue=10 \|pages=1281–1294 \|year=2014 \|last1=Kulshrestha \|first1=Shatavari \|last2=Khan \|first2=Shakir \|last3=Meena \|first3=Ramovatar \|last4=Singh \|first4=Braj R \|last5=Khan \|first5=Asad U \|s2cid=205606245 }}
	* {{cite journal \|doi=10.2147/IJN.S31219 \|pmid=22802686 \|pmc=3396389 \|title=Gold nanoparticles enhance methylene blue– induced photodynamic therapy: A novel therapeutic approach to inhibit Candida albicans biofilm \|journal=International Journal of Nanomedicine \|volume=7 \|pages=3245–57 \|year=2012 \|last1=Khan \|first1=Asad \|last2=Khan \|last3=Azam \|last4=Alam }}		* {{cite journal \|doi=10.2147/IJN.S31219 \|pmid=22802686 \|pmc=3396389 \|title=Gold nanoparticles enhance methylene blue– induced photodynamic therapy: A novel therapeutic approach to inhibit Candida albicans biofilm \|journal=International Journal of Nanomedicine \|volume=7 \|pages=3245–57 \|year=2012 \|last1=Khan \|first1=Asad \|last2=Khan \|last3=Azam \|last4=Alam }}
	* {{cite journal \|doi=10.1371/journal.pone.0091736 \|pmid=24622055 \|pmc=3951425 \|title=Inhibition of Major Virulence Pathways of Streptococcus mutans by Quercitrin and Deoxynojirimycin: A Synergistic Approach of Infection Control \|journal=PLOS ONE \|volume=9 \|issue=3 \|pages=e91736 \|year=2014 \|last1=Hasan \|first1=Sadaf \|last2=Singh \|first2=Kunal \|last3=Danisuddin \|first3=Mohd \|last4=Verma \|first4=Praveen K \|last5=Khan \|first5=Asad U \|bibcode=2014PLoSO...991736H }}		* {{cite journal \|doi=10.1371/journal.pone.0091736 \|pmid=24622055 \|pmc=3951425 \|title=Inhibition of Major Virulence Pathways of Streptococcus mutans by Quercitrin and Deoxynojirimycin: A Synergistic Approach of Infection Control \|journal=PLOS ONE \|volume=9 \|issue=3 \|pages=e91736 \|year=2014 \|last1=Hasan \|first1=Sadaf \|last2=Singh \|first2=Kunal \|last3=Danisuddin \|first3=Mohd \|last4=Verma \|first4=Praveen K \|last5=Khan \|first5=Asad U \|bibcode=2014PLoSO...991736H \|doi-access=free }}
	* {{cite journal \|doi=10.1371/journal.pone.0056926 \|pmid=23437273 \|pmc=3578935 \|title=Biochemical Characterization of CTX-M-15 from Enterobacter cloacae and Designing a Novel Non-β-Lactam-β-Lactamase Inhibitor \|journal=PLOS ONE \|volume=8 \|issue=2 \|pages=e56926 \|year=2013 \|last1=Faheem \|first1=Mohammad \|last2=Rehman \|first2=Md Tabish \|last3=Danishuddin \|first3=Mohd \|last4=Khan \|first4=Asad U \|bibcode=2013PLoSO...856926F }}		* {{cite journal \|doi=10.1371/journal.pone.0056926 \|pmid=23437273 \|pmc=3578935 \|title=Biochemical Characterization of CTX-M-15 from Enterobacter cloacae and Designing a Novel Non-β-Lactam-β-Lactamase Inhibitor \|journal=PLOS ONE \|volume=8 \|issue=2 \|pages=e56926 \|year=2013 \|last1=Faheem \|first1=Mohammad \|last2=Rehman \|first2=Md Tabish \|last3=Danishuddin \|first3=Mohd \|last4=Khan \|first4=Asad U \|bibcode=2013PLoSO...856926F \|doi-access=free }}
	* {{cite journal \|doi=10.1371/journal.pone.0051850 \|pmid=23251640 \|pmc=3522591 \|title=Inhibition of N-Terminal Lysines Acetylation and Transcription Factor Assembly by Epirubicin Induced Deranged Cell Homeostasis \|journal=PLOS ONE \|volume=7 \|issue=12 \|pages=e51850 \|year=2012 \|last1=Khan \|first1=Shahper N \|last2=Danishuddin \|first2=Mohd \|last3=Varshney \|first3=Bhavna \|last4=Lal \|first4=Sunil K \|last5=Khan \|first5=Asad U \|bibcode=2012PLoSO...751850K }}		* {{cite journal \|doi=10.1371/journal.pone.0051850 \|pmid=23251640 \|pmc=3522591 \|title=Inhibition of N-Terminal Lysines Acetylation and Transcription Factor Assembly by Epirubicin Induced Deranged Cell Homeostasis \|journal=PLOS ONE \|volume=7 \|issue=12 \|pages=e51850 \|year=2012 \|last1=Khan \|first1=Shahper N \|last2=Danishuddin \|first2=Mohd \|last3=Varshney \|first3=Bhavna \|last4=Lal \|first4=Sunil K \|last5=Khan \|first5=Asad U \|bibcode=2012PLoSO...751850K \|doi-access=free }}
	* {{cite journal \|doi=10.1093/jac/dkn253 \|pmid=18565974 \|title=Novel anti-adherence activity of mulberry leaves: Inhibition of Streptococcus mutans biofilm by 1-deoxynojirimycin isolated from Morus alba \|journal=Journal of Antimicrobial Chemotherapy \|volume=62 \|issue=4 \|pages=751–757 \|year=2008 \|last1=Islam \|first1=B \|last2=Khan \|first2=S. N \|last3=Haque \|first3=I \|last4=Alam \|first4=M \|last5=Mushfiq \|first5=M \|last6=Khan \|first6=A. U \|doi-access=free }}		* {{cite journal \|doi=10.1093/jac/dkn253 \|pmid=18565974 \|title=Novel anti-adherence activity of mulberry leaves: Inhibition of Streptococcus mutans biofilm by 1-deoxynojirimycin isolated from Morus alba \|journal=Journal of Antimicrobial Chemotherapy \|volume=62 \|issue=4 \|pages=751–757 \|year=2008 \|last1=Islam \|first1=B \|last2=Khan \|first2=S. N \|last3=Haque \|first3=I \|last4=Alam \|first4=M \|last5=Mushfiq \|first5=M \|last6=Khan \|first6=A. U \|doi-access=free }}
	* {{cite journal \|doi=10.1128/AAC.00366-08 \|pmid=18725447 \|pmc=2573143 \|title=A Plasmid-Borne blaOXA-58 Gene Confers Imipenem Resistance to Acinetobacter baumannii Isolates from a Lebanese Hospital \|journal=Antimicrobial Agents and Chemotherapy \|volume=52 \|issue=11 \|pages=4115–4120 \|year=2008 \|last1=Zarrilli \|first1=R \|last2=Vitale \|first2=D \|last3=Di Popolo \|first3=A \|last4=Bagattini \|first4=M \|last5=Daoud \|first5=Z \|last6=Khan \|first6=A. U \|last7=Afif \|first7=C \|last8=Triassi \|first8=M }}		* {{cite journal \|doi=10.1128/AAC.00366-08 \|pmid=18725447 \|pmc=2573143 \|title=A Plasmid-Borne blaOXA-58 Gene Confers Imipenem Resistance to Acinetobacter baumannii Isolates from a Lebanese Hospital \|journal=Antimicrobial Agents and Chemotherapy \|volume=52 \|issue=11 \|pages=4115–4120 \|year=2008 \|last1=Zarrilli \|first1=R \|last2=Vitale \|first2=D \|last3=Di Popolo \|first3=A \|last4=Bagattini \|first4=M \|last5=Daoud \|first5=Z \|last6=Khan \|first6=A. U \|last7=Afif \|first7=C \|last8=Triassi \|first8=M }}